Hamster Anti-CTLA4 Monoclonal Antibody

• Cat.No.: DMABT-H18898
• Product Overview: Hamster Anti-CTLA4 Monoclonal Antibody

Specification

• Antigen Description: CD152, also known as CTLA-4 or Ly-56, is a44kD member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
• Target: CTLA4
• Immunogen: Mouse CTLA-4-mouse IgG2a fusion protein
• Host: Hamster
• Isotype: IgG
• species: Mouse
• Clone: VD20-5C0
• Conjugation: APC
• Applications: Flow Cyt
• Preparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
• Usage recommendation: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 μg per million cells in 100 μl volume. It is recommended that the reagent be titrated for optimal performance for each application.
• Concentration: 0.2 mg/ml
• Storage: The antibody solution should be stored undiluted at 4 °C and protected from prolonged exposure to light.Do not freeze.
• Size: 25 μg;100 μg

Gene Information

• Gene Name: Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus ]
• Official Symbol: CTLA4
• Synonyms: CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4; Cd152; Ly-56; Ctla-4
• Gene ID: 12477
• mRNA Refseq: NM_009843
• Protein Refseq: NP_033973
• Pathway: Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem