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Cat.No.
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CAB-6197RH
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Product Overview
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Rabbit Anti-SPTAN1 Monoclonal Antibody
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Antigen Description
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Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes. Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that has been implicated in the establishment of specialized membrane- cytoskeletal domains in differentiating cells (2-3). Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells, or treatment of cells with staurosporine, dexamethasone, or synthetic ceramide. The major products of the cleavage are amino-terminal (135 kDa) and carboxy-terminal (150 kDa and 120 kDa) fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis, and are valuable in the evaluation fo Sicca- and Sjögren"s syndrome (5-6).
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Target
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SPTAN1
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Immunogen
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A synthetic peptide corresponding to residues in human SPTAN1 was used as an immunogen.
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Host
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Rabbit
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Species
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Human
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Clone
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MAAG3644
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conjugation
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N/A
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Applications
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WB
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Format
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50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage
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SPTAN1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
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Antigen Gene Information
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Gene Name
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SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) [ Homo sapiens ]
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Official Symbol
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SPTAN1
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Synonyms
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SPTAN1; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); spectrin alpha chain, brain; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; NEAS; EIEE5; SPTA2; FLJ17738; FLJ44613;
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GeneID
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6709
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mRNA Refseq
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NM_001130438
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Protein Refseq
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NP_001123910
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MIM
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182810
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UniProt ID
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Q13813
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Chromosome Location
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9q34.11
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Pathway
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Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem;
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Function
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actin binding; calcium ion binding; calmodulin binding; protein binding; structural constituent of cytoskeleton;
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