Catalog # or name ...
Rabbit Anti-SPTAN1 Monoclonal Antibody
Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes. Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that has been implicated in the establishment of specialized membrane- cytoskeletal domains in differentiating cells (2-3). Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells, or treatment of cells with staurosporine, dexamethasone, or synthetic ceramide. The major products of the cleavage are amino-terminal (135 kDa) and carboxy-terminal (150 kDa and 120 kDa) fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis, and are valuable in the evaluation fo Sicca- and Sjögren"s syndrome (5-6).
A synthetic peptide corresponding to residues in human SPTAN1 was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
SPTAN1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Antigen Gene Information
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) [ Homo sapiens ]
SPTAN1; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); spectrin alpha chain, brain; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; NEAS; EIEE5; SPTA2; FLJ17738; FLJ44613;
Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem;
actin binding; calcium ion binding; calmodulin binding; protein binding; structural constituent of cytoskeleton;
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