Native Human TNNI3
Cat.No. : | TNNI3-221H |
Product Overview : | Native Human TNNI3 was purified from Human cardiac tissue by Tn-C affinity chromatography. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TNNI3-221H |
Description : | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). |
Source : | Human cardiac tissue |
Molecular Mass : | 24 KDa |
Formulation : | Liquid |
Storage buffer : | 8 M Urea, 50 mM Tris.HCl, 15 mM ß-mercaptoethanol, 1 mM EDTA (pH 8.0) |
Applications : | This peptide can be used with studies using ab7829, ab8290, ab8291 and ab137719. |
Biological activity : | SDS PAGE profile of a typical recombinant Troponin-I preparation (3.8ug) showed a major band at 24kDa and a minor band attributable to Troponin-I dimer. Please note: Troponin-I is very susceptible to proteolytic breakdown within cardiac tissue and it is difficult to isolate undegraded native human cardiac troponin-I. This product is greater than 70% intact and hence proteolytic fragments can be observed. |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
OfficialSymbol : | TNNI3 |
Gene Name : | TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ] |
Synonyms : | TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; MGC116817; TNNI3; troponin I, cardiac; Troponin I, cardiac muscle; Cardiac troponin I; familial hypertrophic cardiomyopathy 7 |
Gene ID : | 7137 |
mRNA Refseq : | NM_000363 |
Protein Refseq : | NP_000354 |
MIM : | 191044 |
UniProt ID : | P19429 |
Chromosome Location : | 19q13.4 |
Pathway : | Hypertrophic cardiomyopathy (HCM); Muscle contraction; Cardiac muscle contraction |
Function : | actin binding; calcium-dependent protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; calcium channel inhibitor activity |
Products Types
◆ Recombinant Protein | ||
TNNI3-9497M | Recombinant Mouse TNNI3 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNNI3-2682H | Recombinant Human TNNI3 protein(61-130 aa), C-His-tagged | +Inquiry |
Tnni3-1388M | Recombinant Mouse Tert Protein, His-SUMO-tagged | +Inquiry |
TNNI3-873H | Recombinant Human TNNI3 Protein, His-tagged | +Inquiry |
TNNI3-008H | Recombinant Human TNNI3 Protein | +Inquiry |
◆ Native Protein | ||
TNNI3-223H | Native Human Troponin I Type 3 (Cardiac) | +Inquiry |
TNNI3-01H | Native Human TNNI3 Protein | +Inquiry |
Tnni3-7423M | Native Mouse Tnni3 Protein | +Inquiry |
◆ Lysates | ||
TNNI3-1803HCL | Recombinant Human TNNI3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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