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Recombinant Human NFKB2, GST-tagged

Cat.No. : NFKB2-4859H
Product Overview : Recombinant human NFKB2 (1-454) was expressed in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.?
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~84 kDa
Protein length : 1-454
Purity : >75%
Applications : Western Blot
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.2 ug/ul
Gene Name : NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [ Homo sapiens ]
Official Symbol : NFKB2
Synonyms : NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear factor of kappa light chain gene enhancer in B-cells 2; H2TF1; LYT10; LYT-10; NF-kB2
Gene ID : 4791
mRNA Refseq : NM_002502
Protein Refseq : NP_002493
MIM : 164012
UniProt ID : Q00653
Chromosome Location : 10q24
Pathway : Cytokine Signaling in Immune system; DEx/H-box helicases activate type I IFN and inflammatory cytokines production; Epstein-Barr virus infection
Function : DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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