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Rabbit Anti-CHEK1 Monoclonal Antibody
Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression. Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345. Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c. Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase.
A phospho-specific peptide corresponding to residues surrounding Serine 280 of human Chk1 was used as an immunogen. The antibody only detects Chk1 phosphorylated on Serine 280.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Chk1 Antibody Phospho (pS280) can be stored at -20°C for up to 12 months from time of receipt.
Antigen Gene Information
CHEK1 checkpoint kinase 1 [ Homo sapiens ]
CHEK1; checkpoint kinase 1; CHK1 (checkpoint, S.pombe) homolog , CHK1 checkpoint homolog (S. pombe); serine/threonine-protein kinase Chk1; CHK1; Chk1-S; checkpoint kinase-1; CHK1 checkpoint homolog; cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1;
Activation of ATR in response to replication stress, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystem;
ATP binding; histone kinase activity (H3-T11 specific); nucleotide binding; protein binding; protein serine/threonine kinase activity;
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