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Mouse Anti-TREM1 Monoclonal Antibody

Cat.No. : DMABT-H18610
Product Overview : Mouse Anti-TREM1 Monoclonal Antibody
  • Specification
  • Gene Information
  • Related Products
Antigen Description : TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock.
Target : TREM1
Immunogen : Recombinant human TREM-1
Host : Mouse
Isotype : IgG1, kappa
species : Human
Conjugation : APC
Applications : Flow Cyt
Preparation : The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Usage recommendation : Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis.Test size products are transitioning from 20 μl to 5 μl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 μl staining volume or per 100 μl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
Storage : The antibody solution should be stored undiluted at 4 °C and protected from prolonged exposure to light.Do not freeze.
Size : 100 tests
Gene Name : TREM1 triggering receptor expressed on myeloid cells2[ Homo sapiens ]
Official Symbol : TREM1
Synonyms : TREM1; triggering receptor expressed on myeloid cells 1; CD354; TREM 1; triggering-receptor TREM1; triggering receptor expressed on monocytes 1; TREM-1;
Gene ID : 54210
mRNA Refseq : NM_001242589
Protein Refseq : NP_001229518
MIM : 605085
UniProt ID : Q9NP99
Chromosome Location : 6p21.1
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function : receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does TREM1 protein have antimicrobial effects? 11/03/2019

TREM1 protein can enhance inflammatory response during infection, but its specific relationship with antibacterial effect still needs further study.

What is the role of TREM1 protein in the treatment of lung diseases? 08/25/2019

High expression of the TREM1 protein in lung disease can trigger an excessive inflammatory response, and controlling its activity may help reduce the symptoms and inflammatory damage of lung disease.

How is the TREM1 protein related to bacterial infections? 04/22/2019

When bacterial infection occurs, the expression of the TREM1 protein increases, which enhances the inflammatory response, which helps clear the infection and regulate the inflammatory process.

What immune response is the TREM1 protein involved in? 03/20/2019

TREM1 protein is involved in immune response processes such as macrophage activation, release of inflammatory mediators, and recruitment and regulation of immune cells.

What are the implications of the study of TREM1 protein for the treatment of inflammatory diseases? 02/04/2019

The study of TREM1 protein helps to understand the regulatory mechanism of inflammatory response and provide new targets and strategies for the treatment of inflammatory diseases.

Does the TREM1 protein have the potential to predict and monitor disease progression? 01/12/2019

High expression of the TREM1 protein is associated with the development and prognosis of certain diseases and can therefore serve as a biomarker for predicting and monitoring disease progression.

Customer Reviews (3)

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Reviews
05/19/2022

    The exceptional stability of TREM1 makes it an invaluable tool for a wide range of applications.

    01/18/2020

      Manufacturer's commitment to environmental sustainability is evident in its production processes, using green and renewable resources.

      10/06/2019

        TREM1 has a short half-life, making it more effective and less likely to cause side effects compared to other similar proteins.

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