Recombinant Human CTSK

• Cat.No.: CTSK-690H
• Product Overview: Recombinant Human CTSK was expressed in insect cells.

Specification

• Cat. No.: CTSK-690H
• Description: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.
• Source: Insect cells
• Molecular Mass: ~26kDa
• Purity: ≥95% as determined by SDS­PAGE.
• Concentration: 0.023mg/ml
• Formulation: Liquid. In 50mM sodium acetate, pH 5.5, containing 50mM sodium chloride, 0.5mM EDTA and 5mM DTT.
• Specific Activity: ≥1''500mU/mg protein.One unit is defined as the amount of enzyme that will hydrolyze 1µmol Z-Phe-Arg-AMC substrate per min. at 37oC in 50mM sodium acetate, pH 5.5, containing 2.5mM EDTA, 0.01% Trition X-100 and 1mM DTT.
• Storage: Stable for at least 6 months after receipt when stored at -80°C.
• OfficialSymbol: CTSK

Gene Information

• Gene Name: CTSK cathepsin K [ Homo sapiens ]
• Synonyms: CTSK; cathepsin K; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; MGC23107; cathepsin K; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2; OTTHUMP00000032938
• Gene ID: 1513
• mRNA Refseq: NM_000396
• Protein Refseq: NP_000387
• MIM: 601105
• UniProt ID: P43235
• Chromosome Location: 1q21
• Pathway: Lysosome; Osteoclast Signaling; Osteoclast differentiation; Rheumatoid arthritis; Toll-like receptor signaling pathway
• Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity