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Mouse Anti-Human CDK7 Monoclonal Antibody

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Cat.No.

CAB-10468MH

Product Overview

Mouse Anti-CDK7 Monoclonal Antibody

Antigen Description

Cyclin-dependent kinase 7 (CDK7) has essential roles in the cell-division cycle as a CDK-activating kinase (CAK) and in the transcription as a component of the general transcription factor TFIIH. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK), phosphorylating cell-cycle CDKs. It is also an essential component of the transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of the largest subunit of Pol II. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. Embryonic stem cells (ESCs) shows a very unusual cell cycle structure, characterized by a short G1 phase and a high proportion of cells in S-phase. This is associated with a unique mechanism of cell cycle regulation by the activity of cyclin dependent protein kinase (Cdk). The unique cell cycle structure and mechanism of cell cycle control indicates that the cell cycle machinery plays a role in establishment or maintenance of the stem cell state.

Target

CDK7

Immunogen

Recombinant human protein purified from E.coli(His/ABD-CDK7 136-346 a.a.)

Host

Mouse

Isotype

IgG2a, K

Species

Human

Clone

4F4

conjugation

N/A

Applications

ELISA,WB,IP

Storage

Store for 1 year at -20°C from date of shipment

Antigen Gene Information

Gene Name	CDK7 cyclin-dependent kinase 7 [ Homo sapiens ]
Official Symbol	CDK7
Synonyms	CDK7; cyclin-dependent kinase 7; cyclin dependent kinase 7 (homolog of Xenopus MO15 cdk activating kinase) , cyclin dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk activating kinase); CAK; CAK1; CDKN7; MO15; STK1; p39 Mo15; protein kinase; 39 KDa protein kinase; kinase subunit of CAK; CDK-activating kinase 1; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine-protein kinase 1; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); HCAK; p39MO15;
GeneID	1022
mRNA Refseq	NM_001799
Protein Refseq	NP_001790
MIM	601955
UniProt ID	P50613
Chromosome Location	5q12.1
Pathway	Androgen Receptor Signaling Pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function	ATP binding; DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; androgen receptor binding; cyclin-dependent protein kinase activity; nucleotide binding; protein C-terminus binding; protein complex binding; protein kinase activity; transcription coactivator activity;

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Mouse Anti-Human CDK7 Monoclonal Antibody

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