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Antigen Description
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Delta-like protein
1, also known as Drosophila Delta homolog 1, H-Delta-1, and DLL1, is a
single-pass type I membrane protein which contains one DSL domain
and eight EGF-like domains. DLL1 is expressed in heart and pancreas, with
lower expression in brain and muscle and almost no expression in placenta,
lung, liver and kidney. DLL1 acts as a ligand for Notch receptors. DLL1
blocks the differentiation of progenitor cells into the B-cell lineage while
promoting the emergence of a population of cells with the characteristics of
a T-cell/NK-cell precursor. The Notch pathway is an evolutionary conserved
intercellular signaling pathway involved in numerous biological processes
including cell fate determination, cellular differentiation, proliferation,
survival, and apoptosis. In mammalian cells, five Notch ligands (Jagged1, 2,
DLL1, DLL3, DLL4) and four Notch receptors (Notch 1-4) have been identified,
and ligand-receptor interactions results in proteolysis and translocation of
the Notch intracellular domain. Analysis of DLL1 mutants reveals that it is
necessary and sufficient to maintain a pool of progenitors in the embryonic
neuroepithelium. DLL1 serves to prevent the untimely differentiation of
neural progenitors. DLL1 also contributes to the control of proliferation and
differentiation in (Interfollicular Epidermis) IFE.
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Specificity
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Human DLL1/Delta-1. No
cross-reactivity in WB and ELISA with Mouse DLL4/Delta-4, Mouse
DLL1/Delta-1, Mouse DLL1/Delta-1, Human DLL4/Delta-4 and Human cell lysate
(293 cell line).
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