Catalog # or name ...
1, also known as Drosophila Delta homolog 1, H-Delta-1, and DLL1, is a
single-pass type I membrane protein which contains one DSL domain
and eight EGF-like domains. DLL1 is expressed in heart and pancreas, with
lower expression in brain and muscle and almost no expression in placenta,
lung, liver and kidney. DLL1 acts as a ligand for Notch receptors. DLL1
blocks the differentiation of progenitor cells into the B-cell lineage while
promoting the emergence of a population of cells with the characteristics of
a T-cell/NK-cell precursor. The Notch pathway is an evolutionary conserved
intercellular signaling pathway involved in numerous biological processes
including cell fate determination, cellular differentiation, proliferation,
survival, and apoptosis. In mammalian cells, five Notch ligands (Jagged1, 2,
DLL1, DLL3, DLL4) and four Notch receptors (Notch 1-4) have been identified,
and ligand-receptor interactions results in proteolysis and translocation of
the Notch intracellular domain. Analysis of DLL1 mutants reveals that it is
necessary and sufficient to maintain a pool of progenitors in the embryonic
neuroepithelium. DLL1 serves to prevent the untimely differentiation of
neural progenitors. DLL1 also contributes to the control of proliferation and
differentiation in (Interfollicular Epidermis) IFE.
Recombinant human DLL1
Human DLL1/Delta-1. No
cross-reactivity in WB and ELISA with Mouse DLL4/Delta-4, Mouse
DLL1/Delta-1, Mouse DLL1/Delta-1, Human DLL4/Delta-4 and Human cell lysate
(293 cell line).
filtered solution in PBS with 5% trehalose.
antibody can be used at 0.1~0.2 μg/mL with the appropriate secondary
reagents to detect human DLL1 in WB. Using a DAB detection system, the
detection limit for human DLL1 is approximately 2 ng/lane under
non-reducing conditions. Use of this antibody under reducing conditions is
not recommended; ELISA-This antibody can be used at 0.5~1μg/mL with
the appropriate secondary reagents to detect human DLL1. The detection limit
for human DLL1 is 0.039 ng/well.
This antibody can be
stored at 2oC~8oC for one month without detectable loss of activity. Antibody
products are stable for twelve months from date of receipt when stored at
-20oC to -70oC. Preservative-Free. Sodium azide is recommended to avoid
contamination (final concentration 0.05%~0.1%). It is toxic to cells and
should be disposed of properly. Avoid repeated freeze-thaw cycles.
Antigen Gene Information
DLL1 delta-like 1 (Drosophila)
[Homo sapiens ]
DLL1; delta-like 1
(Drosophila); DL1; Delta; DELTA1; delta-like protein 1; H-Delta-1; delta-like
1 protein; drosophila Delta homolog 1; delta (Drosophila)-like 1; Delta1
pathway; Delta-Notch Signaling Pathway
calcium ion binding; protein binding
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