Rabbit Anti-Human PVR Monoclonal Antibody

Cat.No.

CAB-9578RH

Product Overview

Rabbit Anti-PVR Monoclonal Antibody

Antigen Description

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein. It belongs to the nectins and nectin-like (Necl) subfamily and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. CD155 undergoes cell-matrix contacts by binding to the matrix protein Vitronectin. Along with the receptor form, three soluble isoforms, μ, μ and μ, exist in human serum and cerebrospinal fluid, and CD155 mRNAs are highly expressed in liver tissue. The presence of soluble CD155 reduces polivirus entry mediated by the membrane-bound receptor, implying an important role for these soluble forms in cellular function.

specificity

Human CD155 / PVR. No cross-reactivity with human cell lysate (293 cell line) in WB and ELISA.

Target

PVR

Immunogen

Recombinant human CD155 protein.

Host

Rabbit

Isotype

Rabbit IgG

Species

Human

Clone

CBSB166CB

conjugation

N/A

Applications

d-ELISA,WB

Format

0.2μm filtered solution in PBS with 5% trehalose.

Storage

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -70°C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Antigen Gene Information