Catalog # or name ...
Rabbit Anti-PVR Monoclonal Antibody
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein. It belongs to the nectins and nectin-like (Necl) subfamily and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. CD155 undergoes cell-matrix contacts by binding to the matrix protein Vitronectin. Along with the receptor form, three soluble isoforms, μ, μ and μ, exist in human serum and cerebrospinal fluid, and CD155 mRNAs are highly expressed in liver tissue. The presence of soluble CD155 reduces polivirus entry mediated by the membrane-bound receptor, implying an important role for these soluble forms in cellular function.
Human CD155 / PVR. No cross-reactivity with human cell lysate (293 cell line) in WB and ELISA.
Recombinant human CD155 protein.
0.2μm filtered solution in PBS with 5% trehalose.
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -70°C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Antigen Gene Information
PVR poliovirus receptor [ Homo sapiens ]
PVR; poliovirus receptor; PVS; CD155; HVED; Necl 5; NECL5; nectin like 5; Tage4; nectin-like 5; nectin-like protein 5; TAGE4; Necl-5; FLJ25946;
Adaptive Immune System, organism-specific biosystem; Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;
cell adhesion molecule binding; protein binding; receptor activity;
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