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Rat Anti-Timd2 Monoclonal Antibody

Cat.No.: DMAB36387
Product Overview: Rat Anti-Timd2 Monoclonal Antibody
Antigen Description: Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.
specificity: It specifically recognises mouse Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells.
Target: Timd2
Immunogen: Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a.
Host: Rat
Isotype: IgG2a
species: Mouse
Clone: SNU3-36
Purification: Purified IgG
Conjugation: N/A
Applications: Flow Cyt,IP,WB
Dilution: Flow Cytometry:1/25 - 1/200
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Protein Concentration: 1 mg/ml
Storage: Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Preservative: 0.09% Sodium Azide (NaN3)
Shelf life: 18 months from date of despatch.
Size: 0.1 mg
Gene Name: Timd2 T cell immunoglobulin and mucin domain containing 2 [ Mus musculus ]
Official Symbol: Timd2
Synonyms: TIMD2; T cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; TIMD-2; T-cell membrane protein 2; T-cell immunoglobulin and mucin domain containing 2; G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662;
Gene ID: 171284
mRNA Refseq: NM_001161355
Protein Refseq: NP_001154827
Function: receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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