Recombinant Human TDO2 protein, His-tagged

• Cat.No.: TDO2-724H
• Product Overview: Recombinant Human TDO2(2-406 aa) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween 20, 20% glycerol, 440 mM Imidazole
• Molecular Mass: 49 kDa
• Purity: >92%
• Applications: Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
• Storage: At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
• Concentration: 0.65 mg/ml

Gene Information

• Gene Name: TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens ]
• Official Symbol: TDO2
• Synonyms: TDO2; tryptophan 2,3-dioxygenase; TDO; TPH2; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase; TO; TRPO
• Gene ID: 6999
• mRNA Refseq: NM_005651
• Protein Refseq: NP_005642
• MIM: 191070
• UniProt ID: P48775
• Chromosome Location: 4q31-q32
• Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Monoamine Transport, organism-specific biosystem; NAD biosynthesis II (from tryptophan), organism-specific biosystem; NAD biosynthesis II (from tryptophan), conserved biosystem; Tryptophan catabolism, organism-specific biosystem
• Function: amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; tryptophan 2,3-dioxygenase activity