Catalog # or name ...
A DNA sequence
encoding the human ADRBK1 ( NP_001610.2 ) ( Met 1 - Leu 689 ) was fused with
the N-terminal polyhistidine-tagged GST tag at the N-terminus.
ADRBK1 is a member
of the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK
subfamily. ADRBK1 contains one AGC-kinase C-terminal domain, one PH domain,
one protein kinase domain and one RGS domain. ADRBK1 is expressed in
peripheral blood leukocytes. It is a key regulator of LPAR1 signaling.
Lyophilized from sterile
50mM Tris, 500mM NaCl, 0.5mM GSH, pH 8.0. Normally 5 % - 8 % trehalose and
mannitol are added as protectants before lyophilization. Specific
concentrations are included in the hardcopy of COA.
> 90 % as
determined by SDS-PAGE
EU per μg protein as determined by the LAL method
are stable for up to twelve months from date of receipt at -70oC.
Predicted N terminal
recombinant human ADRBK1/GST chimera consists of 926 amino acids and has a
calculated molecular mass of 107 kDa. It migrates as an approximately 110 kDa
band in SDS-PAGE under reducing conditions.
Store it under
sterile conditions at -70oC
upon receiving. Recommend to aliquot the protein into smaller quantities for
optimal storage. Avoid repeated freeze-thaw cycles.
Antigen Gene Information
ADRBK1 adrenergic, beta, receptor kinase 1
[ Homo sapiens ]
ADRBK1; adrenergic, beta, receptor kinase 1; GRK2;
BARK1; FLJ16718; BETA-ARK1; beta-adrenergic receptor kinase 1; beta-ARK-1;
OTTHUMP00000235171; G-protein coupled receptor kinase 2; EC 22.214.171.124; Beta-adrenergic
receptor kinase 1; Beta-ARK-1
CXCR4-mediated signaling events;
Ca-dependent events; CaM pathway; Calmodulin induced events; Chemokine
signaling pathway; Endocytosis; G alpha (q) signalling events; G-protein
mediated events; GPCR downstream signaling; Glutamatergic synapse; NGF
signalling via TRKA from the plasma membrane; Opioid Signalling; PLC beta
mediated events; PLC-gamma1 signalling; Signaling by GPCR
ATP binding; nucleotide binding; protein
binding; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled
receptor kinase activity; alpha-2A adrenergic receptor binding;
beta-adrenergic receptor kinase activity; protein kinase activity; signal transducer
PDB renderingbased on 1bak
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