Recombinant Human Alpha-2-HS-Glycoprotein
Cat.No. : | AHSG-4356H |
Product Overview : | The human Alpha-2-HS-Glycoprotein was purified from the human plasma. |
- Specification
- Gene Information
- Related Products
Cat. No. : | AHSG-4356H |
Description : | Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains. Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation. Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis. |
Source : | Human |
Host : | Purified from the human plasma. |
Form : | Filtered (0.4µm) and lyophilized from 0.5 mg/ml in PBS pH 7.4. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Filtered White lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Storage : | Store the lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C. |
Functions : | cysteine-type endopeptidase inhibitor activity; kinase inhibitor activity; protein binding |
Gene Name : | AHSG alpha-2-HS-glycoprotein [ Homo sapiens ] |
Official Symbol : | AHSG |
Synonyms : | AHSG; alpha-2-HS-glycoprotein; AHS; A2HS; HSGA; FETUA; fetuin-A; Ba-alpha-2-glycoprotein; Alpha-2-Z-globulin; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; PRO2743 |
Gene ID : | 197 |
mRNA Refseq : | NM_001622 |
Protein Refseq : | NP_001613 |
MIM : | 138680 |
UniProt ID : | P02765 |
Chromosome Location : | 3q27.3 |
Products Types
◆ Recombinant Protein | ||
AHSG-816H | Recombinant Human AHSG Protein | +Inquiry |
AHSG-298H | Recombinant Human AHSG Protein, His (Fc)-Avi-tagged | +Inquiry |
Ahsg-102G | Recombinant Guinea pig Ahsg Protein, His-tagged | +Inquiry |
Ahsg-705M | Active Recombinant Mouse Ahsg protein(Met1-Ile345), His-tagged | +Inquiry |
AHSG-101C | Recombinant Cattle AHSG Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
AHSG-111H | Native Human Alpha 2 HS Glycoprotein | +Inquiry |
AHSG-1001H | Human Leucine-rich Alpha-2-glycoprotein 1 | +Inquiry |
◆ Lysates | ||
AHSG-2957MCL | Recombinant Mouse AHSG cell lysate | +Inquiry |
AHSG-2958HCL | Recombinant Human AHSG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTechniques like co-immunoprecipitation coupled with mass spectrometry can reveal AHSG's interactome, shedding light on its broader functional networks.
AHSG levels may be altered in these conditions, making it a potential biomarker for disease progression or severity.
AHSG's interaction with insulin and adipokines could impact insulin sensitivity and metabolism, contributing to insulin resistance in conditions like type 2 diabetes.
AHSG can form complexes with fetuin-B and fetuin-A, which have implications for calcium homeostasis, insulin signaling, and other physiological processes.
AHSG can interact with immune cells and cytokines, potentially influencing immune responses. Dysregulated AHSG levels might contribute to autoimmune diseases.
AHSG's interactions with proteins like albumin and hormones can impact its bioavailability and activity, influencing physiological processes.
Techniques such as mass spectrometry, lectin affinity chromatography, and glycan analysis can provide insights into AHSG's glycosylation patterns.
AHSG binds to calcium ions and influences their distribution in the body. Dysregulation may impact bone health and contribute to conditions like osteoporosis.
Techniques such as ion exchange chromatography, gel filtration, and affinity chromatography can be used to isolate and purify AHSG from biological samples.
Genetic polymorphisms in the AHSG gene might lead to altered AHSG levels or structural changes, potentially influencing its physiological roles.
Customer Reviews (5)
Write a reviewAbsolutely loving the lab protein – a real game changer!
Great value for the quality, and the speedy delivery was a pleasant surprise!
Thumbs up for the protein, it's become my new favorite.
Can't help but smile at the results from the product!
Balanced pricing, superior quality, and top-level customer assistance.
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