Active Recombinant Human Brain Derived Neurotrophic Factor
Cat.No. : | BDNF-022H |
Product Overview : | Recombinant Human Brain-Derived Neurotrophic Factor produced in E.Coli is a homodimer , non-glycosylated, polypeptide chain containing 2 x 119 amino acids and having a total molecular mass of 26,984 Dalton. |
- Specification
- Gene Information
- Related Products
Cat. No. : | BDNF-022H |
Description : | BDNF is a member of the nerve growth factor family of trophic factors. Polyclonal antibodies raised against murine NGF have been shown to cross-react with both NT-3 and BDNF. |
Species : | Human |
Source : | E.coli |
Form : | Lyophilized with no additives. |
Purity : | Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
Bio-activity : | BDNF is fully biologically active when compared to standard. The ED50 is calculated by the dose-dependant induction of ACHE (acetylcholine esterase) in rat basal forebrain primary septal culture with a range of 20 - 40 ng/ml. |
Physical Appearance : | Sterile Filtered white lyophilized (freeze-dried) powder. |
Solubility : | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg"s/ml, which can be further diluted into other aqueous solutions. |
Purity Greater than 97% as determined by : | Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
Protein Content determined by : | UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
Endotoxin Level : | Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug. |
Amino acid sequence : | MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR |
Storage : | Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage. |
Gene Name : | BDNF brain-derived neurotrophic factor [ Homo sapiens ] |
Official Symbol : | BDNF |
Synonyms : | BDNF; MGC34632; Abrineurin; neurotrophin; Brain-derived neurotrophic factor; NP_733927.1 5` and 3` partial |
Gene ID : | 627 |
mRNA Refseq : | NM_001143806 |
Protein Refseq : | NP_001137278 |
MIM : | 113505 |
UniProt ID : | P23560 |
Chromosome Location : | 11p13 |
Pathway : | Huntington"s disease; MAPK signaling pathway; Neurotrophin signaling pathway |
Function : | Growth factor activity |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionBDNF levels can be measured through blood tests or cerebrospinal fluid analysis, providing insights into the protein's concentration in the body.
BDNF deficiency has been linked to conditions such as Alzheimer's disease, Parkinson's disease, and depression.
While there are no direct BDNF medications, certain drugs and treatments aim to enhance BDNF levels indirectly, offering potential therapeutic benefits.
Physical exercise has been shown to increase BDNF production, suggesting that exercise could be used as a non-pharmacological intervention to support neurological health.
BDNF is crucial for synaptic plasticity, influencing the strength and efficacy of connections between neurons, which is vital for learning and memory processes.
Customer Reviews (3)
Write a reviewThe BDNF protein is carefully characterized, and its functional properties are well-documented.
With its high purity and bioactivity, BDNF protein ensures reliable and consistent results in a wide range of experimental applications.
The BDNF protein is of exceptional quality and is perfectly suited to meet the experimental needs of researchers.
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