Recombinant Human Bone Morphogenetic Protein Receptor, Type IB, His-tagged

• Cat.No.: BMPR1B-939H
• Product Overview: Recombinant human BMPR1B, a 113 amino acids protein with polyhistidine tag at C-terminus, and has a calculated MW of 13.5 KDa. DTT-reduced protein migrates as 30 KDa protein due to glycosylation.

Specification

• Cat. No.: BMPR1B-939H
• Description: BMPR1B is a protein which in humans is encoded by the BMPR1B gene. Bone morphogenetic proteins (BMPs) signal through the BMP type I and type II receptors to regulate cellular processes, including embryonic development. The type I BMP receptors activin-like kinase (ALK)3 and BMPR1B share a high degree of homology, yet possess distinct signaling roles. Decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro, and BMPR-IB mediates an inhibitory effect on breast cancer cells.
• Source: Bone morphogenetic protein receptor, type IB (rhBMPR1B or BMPR1B), Lys14-Arg126 (Accession O00238) was expressed in HEK 293.
• Species: Human
• Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
• Purity: >97% purity as determined by SDS-PAGE of reduced BMPR1B.
• Endotoxin: Less than 0.01 ng endotoxin per μg BMPR1B.
• Storage: Store at -80°C upon received. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
• Official Symbol: BMPR1B
• Synonyms: BMPR1B; bone morphogenetic protein receptor, type IB; ALK6; ALK-6; CDw293; activin receptor-like kinase 6; serine/threonine receptor kinase; EC 2.7.11.30; OTTHUMP00000161622; CDw293 antigen; BMPR-1B; BMP type-1B receptor; bone morphogenetic protein receptor type-1B; OTTHUMP00000161622; OTTHUMP00000219359; OTTHUMP00000161621; OTTHUMP00000219880; OTTHUMP00000219882
• Gene ID: 658
• mRNA Refseq: NM_001203
• Protein Refseq: NP_001194
• MIM: 603248
• UniProt ID: O00238
• Chromosome Location: 4q22-q24
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP; Ovarian Infertility Genes
• Function: transforming growth factor beta receptor activity, type I; ATP binding; SMAD binding; magnesium ion binding; manganese ion binding; nucleotide binding; receptor activity; transferase activity