Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CD46 protein, His-tagged

Cat.No. : CD46-3962H
Product Overview : Recombinant Human CD46 (Cys35-Asp328) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Cys35
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 33.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Cys35-Asp328
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : CD46
Official Symbol : CD46
Synonyms : CD46; CD46 molecule, complement regulatory protein; antigen identified by monoclonal TRA 2 10 , CD46 antigen, complement regulatory protein , MCP, membrane cofactor protein (CD46, trophoblast lymphocyte cross reactive antigen), MIC10; membrane cofactor protein; MGC26544; TLX; TRA2.10; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MCP; AHUS2; MIC10
Gene ID : 4179
mRNA Refseq : NM_002389
Protein Refseq : NP_002380
MIM : 120920
UniProt ID : P15529

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does CD46 protein interact with other immune system components? 08/20/2021

CD46 protein interacts with complement regulatory proteins and immune cells to regulate immune responses and maintain homeostasis.

What are the potential side effects of targeting CD46 protein for therapy? 01/05/2020

Potential side effects of targeting CD46 protein for therapy may include disturbances in immune regulation and increased susceptibility to infections.

How does the CD46 protein contribute to immune regulation? 08/11/2018

CD46 protein regulates the activation of complement system and modulates T cell responses, contributing to immune regulation.

Can mutations in the CD46 gene lead to genetic disorders? 09/22/2017

Mutations in the CD46 gene have been associated with genetic disorders such as atypical hemolytic uremic syndrome (aHUS) and other complement-related disorders.

Is CD46 protein involved in cancer progression or treatment resistance? 08/07/2016

CD46 protein has been implicated in cancer progression and treatment resistance, particularly in certain types of leukemia and solid tumors.

Customer Reviews (3)

Write a review
Reviews
10/19/2022

    The CD46 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

    08/09/2019

      With the CD46 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

      03/05/2019

        Its unique properties make CD46 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

        Ask a Question for All CD46 Products

        Required fields are marked with *

        My Review for All CD46 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends