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Recombinant Human CDKN1B, His-tagged

Cat.No. : CDKN1B-4729H
Product Overview : Recombinant human CDKN1B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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  • Gene Information
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Cat. No. : CDKN1B-4729H
Description : CDKN1B, also known as cyclin-dependent kinase inhibitor 1B, belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. This protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol
Molecular Weight : 24.2 kDa (218aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Purity : > 90% by SDS - PAGE
Concentration : 0.25 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN AGSVEQTPKK PGLRRRQT
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : Cell cycle; Chronic myeloid leukemia; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Small cell lung cancer
Gene Name : CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [ Homo sapiens ]
Official Symbol : CDKN1B
Synonyms : CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin -dependent kinase inhibitor 1B; p27Kip1; Cyclin-dependent kinase inhibitor p27
Gene ID : 1027
mRNA Refseq : NM_004064
Protein Refseq : NP_004055
MIM : 600778
UniProt ID : P46527
Chromosome Location : 12p13.1-p12
Function : cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase inhibitor activity; transforming growth factor beta receptor, cytoplasmic mediator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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