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Active Recombinant Human Connective Tissue Growth Factor

Cat.No. : CTGF-555H
Product Overview : CTGF has multiple effects on development and differentiation. H-CTGF is comprised of 98 amino acids with a molecular weight of 11.2 kDa.
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  • Gene Information
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Cat. No. : CTGF-555H
Description : CTGF belongs to the CCN family of secreted proteins. CTGF is a member of cysteine rich regulatory proteins playing an important role in mitogenic and chemotaxis. Each protein has an IGF-binding domain, a thrombospoindin type 1 domain and cysteine knot region.
Species : Human
Source : E.coli
Form : Sterile filtered and lyophilized from 1.0 mg/ml 10 mM NaAcetate, pH 6.0.
Purity : Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity : Human CTGF is fully biologically active when compared to standard. Activity is determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 is 0.08 ?C 1.8 μg/ml.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility : Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product at a concentration of 0.1 mg/ml with 5 mM NaAcetate, pH 6.0.
Purity Greater than 98% as determined by : Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by : UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level : Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence : MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA
Storage : Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name : CTGF connective tissue growth factor [ Homo sapiens ]
Official Symbol : CTGF
Synonyms : CTGF; connective tissue growth factor; IGFBP8; CCN2; NOV2; HCS24; MGC102839; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8; OTTHUMP00000017213; Hypertrophic chondrocyte-specific protein 24
Gene ID : 1490
mRNA Refseq : NM_001901
Protein Refseq : NP_001892
MIM : 121009
UniProt ID : P29279
Chromosome Location : 6q23.2
Function : growth factor activity; heparin binding; insulin-like growth factor binding; integrin binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How can CTGF be measured or detected in clinical settings? 12/20/2017

CTGF levels can be measured using various techniques, including enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry.

What are the potential diagnostic applications of CTGF in medicine? 07/18/2017

CTGF levels can serve as diagnostic markers for fibrotic diseases, aiding in the early detection and monitoring of such conditions.

Are there therapeutic implications of targeting CTGF in clinical practice? 03/08/2017

Yes, targeting CTGF is being explored as a potential therapeutic strategy to mitigate fibrosis in various organs and tissues.

In which medical specialties is CTGF protein research particularly relevant? 11/18/2016

CTGF protein research is particularly relevant in specialties such as rheumatology, pulmonology, and dermatology due to its implications in fibrotic diseases.

How does CTGF contribute to fibrosis? 09/13/2016

CTGF plays a crucial role in promoting the formation of fibrous tissue by stimulating the production of extracellular matrix proteins.

Customer Reviews (3)

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Reviews
03/22/2021

    Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.

    08/06/2019

      With their assistance, I can overcome obstacles and optimize my experimental setup.

      09/23/2018

        With the CTGF protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.

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