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Active Recombinant Human F9 protein, His-tagged

Cat.No. : F9-1157H
Product Overview : Recombinant Human F9 protein(AAB59620.1)(Met1-Thr461), fused with His tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its ability to cleave the peptide substrate, Z-D-Arg-Gly-Arg-pNA. The specific activity is >20pmols/min/ug.
Molecular Mass : The secreted recombinant human F9 (pro form) consists of 444 amino acids and predictes a molecular mass of 50 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh F9 is approximately 60-80 kDa due to glycosylation.
Protein Length : Met1-Thr461
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : F9 coagulation factor IX [ Homo sapiens ]
Official Symbol : F9
Synonyms : F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component; F9 p22; FIX F9; factor 9; factor IX F9; serine protease; Christmas factor; plasma thromboplastin component; P19; PTC; HEMB; THPH8; MGC129641; MGC129642;
Gene ID : 2158
mRNA Refseq : NM_000133
Protein Refseq : NP_000124
MIM : 300746
UniProt ID : P00740

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the function of F9 protein? 12/18/2019

The F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.

How do genetic mutations in the F9 protein affect its function? 12/04/2019

Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.

Do F9 protein mutations cause other diseases or affect other physiological processes? 05/27/2019

F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.

What diseases can F9 gene mutations cause? 05/22/2019

Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.

How is the activity of F9 protein determined? 04/08/2019

The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).

What is the structure of F9 protein? 01/31/2019

F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.

Customer Reviews (3)

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04/15/2021

    The short half-life makes this product very safe.

    10/10/2020

      This protein has a wide range of applications and can be used in a variety of experiments.

      03/27/2019

        The method of use is simple, which reduces the experimental time and improves the efficiency.

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