Recombinant Human Fas (TNF Receptor Superfamily, Member 6)
Cat.No. : | FAS-4270H |
Product Overview : | Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids. The FAS antigen is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Cat. No. : | FAS-4270H |
Description : | FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M b-ME. |
Purity : | Greater than 95% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Physical Appearance : | Sterile liquid formulation. |
Storage : | CD95 although stable at 10°C for 5 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
Gene Name : | FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] |
Official Symbol : | FAS |
Synonyms : | FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen |
Gene ID : | 355 |
mRNA Refseq : | NM_000043 |
Protein Refseq : | NP_000034 |
MIM : | 134637 |
UniProt ID : | P25445 |
Chromosome Location : | 10q24.1 |
Pathway : | Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis |
Function : | identical protein binding; kinase binding; transmembrane receptor activity |
Products Types
◆ Recombinant Protein | ||
FAS-3851H | Recombinant Human FAS Protein, His/Flag/StrepII-tagged | +Inquiry |
FAS-243H | Recombinant Human FAS Protein, Fc-tagged | +Inquiry |
FAS-1468R | Recombinant Rhesus Macaque FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-258C | Recombinant Cynomolgus Monkey FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-3850H | Recombinant Human FAS Protein | +Inquiry |
◆ Lysates | ||
FAS-1139RCL | Recombinant Rat FAS cell lysate | +Inquiry |
FAS-2185HCL | Recombinant Human FAS cell lysate | +Inquiry |
FAS-001CCL | Recombinant Cynomolgus FAS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionFAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.
FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.
Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.
FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.
The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.
Customer Reviews (3)
Write a reviewWhen experimenting with FAS, the results are very reproducible.
The stability of FAS products allows them to cope with different experimental conditions and modes of operation.
FAS has high specific activity and can exert strong biological effect at low concentration.
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