Recombinant Human Fibroblast Growth Factor Receptor 1, His-tagged

• Cat.No.: FGFR1-316H
• Product Overview: rh FGFR1 contains C terminal 6 His Tag and has a calculated MW of 42.5 kDa. In DTT-reduced SDS-PAGE, protein migrates as 60 - 65 kDa.

Specification

• Cat. No.: FGFR1-316H
• Description: Fibroblast growth factor receptor 1 (FGFR1) is also known as basic fibroblast growth factor receptor 1(BFGFR1), FMS-like tyrosine kinase, CD331, and is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is one of several fibroblast growth factor receptors, which are related proteins that are involved in important processes such as cell division regulation of cell growth and maturation formation of blood vessels involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and embryonic development.
• Source: Recombinant human FGFR1 (rh FGFR1) Met1- Ile376 (Accession AAH18128) fused with C terminal 6 His Tag was expressed in human 293 cells (HEK293).
• Species: Human
• Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH7.4 and delivered as liquid formulation or lyophilized powder Normally 5-8% trehalose and mannitol are powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
• Purity: >95% purity as determined by SDS-PAGE of reduced rh FGFR1.
• Endotoxin: Less than 0.01 ng endotoxin per μg rh FGFR1.
• Storage: Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles.
• Publication:
  FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis. (2015)

Gene Information

• Gene Name: FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
• Official Symbol: FGFR1
• Synonyms: FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; FGFR-1; HBGFR; N-SAM; FLJ99988; bFGF-R-1; soluble FGFR1 variant 1; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; EC 2.7.10.1; OTTHUMP00000190881; OTTHUMP00000190885; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880
• Gene ID: 2260
• mRNA Refseq: NM_015850
• Protein Refseq: NP_056934
• MIM: 136350
• UniProt ID: P11362
• Chromosome Location: 8p12
• Pathway: Adherens junction; MAPK signaling pathway; elanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Axon guidance; Signaling by FGFR
• Function: ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; transferase activity