Recombinant Rat Il17a protein
Cat.No. : | Il17a-489R |
Product Overview : | Recombinant Rat Il17a protein was expressed in Escherichia coli. |
- Specification
- Gene Information
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Description : | Cytokine; may be involved in immune system function or to cell death and cell survival. |
Source : | E.coli |
Species : | Rat |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 2 × PBS, pH 6.5. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 10⁶ IU/mg. |
Molecular Mass : | Approximately 30.0 kDa, a disulfide-linked homodimer of two 133 amino acid polypeptide chains. |
Protein length : | 133 |
AA Sequence : | AVLIPQSSVCPNAEANNFLQNVKVN LKVINSLSSKASSRRPSDYLNRSTS PWTLSRNEDPDRYPSVIWEAQCRHQ RCVNAEGKLDHHMNSVLIQQEILVL KREPEKCPFTFRVEKMLVGVGCTCV SSIVRHAS |
Endotoxin : | Less than 0.1 EU/µg of rRtIL-17A as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | Il17a |
Official Symbol : | Il17a |
Synonyms : | IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Il17; IL-17; CTLA-8; IL-17A; |
Gene ID : | 301289 |
mRNA Refseq : | NM_001106897 |
Protein Refseq : | NP_001100367 |
UniProt ID : | Q61453 |
Products Types
◆ Recombinant Protein | ||
IL17A-001C | Recombinant Cynomolgus Monkey IL17A Protein | +Inquiry |
Il17a-253I | Active Recombinant Mouse Il17a Protein (133 aa) | +Inquiry |
IL17A-48H | Recombinant Human IL17A Protein | +Inquiry |
IL17A-138H | Active Recombinant Human IL-17AF Heterodimer Protein | +Inquiry |
IL17A-137H | Active Recombinant Human IL17A Protein | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
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