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Recombinant Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase), GST-Tagged

Cat.No. : MMP3-1383H
Product Overview : MMP-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain fused to a GST tag containing 228 amino acids (251-478) and having a total molecular mass of 51kDa. MMP-3 is purified by proprietary chromatographic techniques.
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Cat. No. : MMP3-1383H
Description : MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta.
Source : Human
Host : Escherichia Coli.
Form : MMP-3 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Physical Appearance : Sterile Filtered clear solution.
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ]
Official Symbol : MMP3
Synonyms : MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104; stromelysin-1; transin-1; proteoglycanase; OTTHUMP00000045949; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Stromelysin-1; Matrix metalloproteinase-3; Transin-1; EC 3.4.24
Gene ID : 4314
mRNA Refseq : NM_002422
Protein Refseq : NP_002413
MIM : 185250
UniProt ID : P08254
Chromosome Location : 11q22.3
Pathway : Matrix Metalloproteinases; Rheumatoid arthritis; p75(NTR)-mediated signaling
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; protein complex binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling? 10/21/2022

MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation? 07/04/2022

MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions? 10/19/2021

Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation? 07/01/2021

MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

What role does MMP3 play in the progression of arthritis and joint degeneration? 09/03/2019

MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

What are the mechanisms by which MMP3 modulates inflammatory responses? 06/13/2019

MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

How does MMP3 contribute to wound healing and tissue repair processes? 12/31/2018

MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.

Customer Reviews (3)

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Reviews
12/05/2020

    Critical expertise in protein engineering, a trusted partner in research.

    03/21/2020

      Swift and reliable protein sequencing, a key asset for our work.

      01/22/2020

        High-quality protein crystallography services, consistently delivers exceptional outcomes.

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