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Recombinant Human Lin-28 Homolog A (C. elegans), His-tagged

Cat.No. : PF4V1-257H
Product Overview : CXCL4 Variant-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa. The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus and purified by standard chromatogrpahy techniques.
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  • Gene Information
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Cat. No. : PF4V1-257H
Description : Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
Source : Human
Host : Escherichia Coli
Form : The protein was lyophilized without additives.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance : Sterile Filtered white lyophilized powder.
Amino acid sequence : MHHHHHHEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES.
Storage : Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Pathways : Cell surface interactions at the vascular wall; Chemokine signaling pathway; Common Pathway; Cytokine-cytokine receptor interaction; Formation of Fibrin Clot (Clotting Cascade); Hemostasis
Gene Name : PF4V1 platelet factor 4 variant 1 [ Homo sapiens ]
Official Symbol : PF4V1
Synonyms : PF4V1; platelet factor 4 variant 1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1; platelet factor 4 variant; PF4alt; PF4var1; OTTHUMP00000160680; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like); PF4var1; C-X-C motif chemokine 4 variant
Gene ID : 5197
mRNA Refseq : NM_002620
Protein Refseq : NP_002611
MIM : 173461
UniProt ID : P10720
Chromosome Location : 4q12-q21
Function : chemokine activity; heparin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the implications for assessing the role of LIN28A in disease? 05/25/2022

The role of LIN28A in disease can be assessed through in-depth analysis of the patient's genomic data and combined with the results of studies in cell and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.

Which biomolecules can be used as molecular markers for LIN28A? 04/28/2022

Certain biomolecules can be used as molecular markers of LIN28A, such as mRNA or protein of LIN28A detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

How can LIN28A-related treatment strategies be considered in clinical practice? 01/25/2022

In clinical practice, treatment strategies related to LIN28A need to consider the patient's specific condition, genotype, and treatment goals. Doctors can develop a personalized treatment plan based on the patient's actual situation to improve the treatment effect and maximize the patient's quality of life. At the same time, long-term follow-up and studies are needed to assess the effectiveness and safety of treatment strategies.

How can I study the function of LIN28A experimentally? 01/06/2022

The function of LIN28A can be studied through cell models and animal models. For example, the expression of LIN28A can be manipulated by gene knockout or overexpression techniques and then observed for its effects on cell biology and animal behavior.

What are the treatment strategies for LIN28A? 03/17/2021

Therapeutic strategies for LIN28A include inhibiting its expression, modulating its activity, or using gene therapy. For example, some small molecule inhibitors can inhibit the activity of LIN28A, thereby treating some LIN28A-related diseases.

How can the relationship between LIN28A and disease be analyzed by bioinformatics methods? 07/22/2020

The effect of LIN28A on disease can be predicted by comparing the expression level, sequence, and structure in different disease tissues and normal tissues. This could help scientists better understand the role of LIN28A in disease.

Customer Reviews (3)

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Reviews
09/07/2023

    LIN28A is green and environmentally friendly, and has little harm to the human body.

    07/22/2021

      It is easy to adhere to the surface of the material, reducing the loss of reagents and reducing costs.

      04/25/2020

        The preparation cost is low and cost-effective.

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