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Active Recombinant Human Peroxiredoxin 2, His-tagged

Cat.No. : PRDX2-1438H
Product Overview : PRDX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass of 21.8 kDa. The PRDX2 is purified by proprietary chromatographic techniques.
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Cat. No. : PRDX2-1438H
Description : PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells. T-cells. PRDX2 has proliferative effect in cancer development or progression. If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer"s or DNA damage leading to cancer.
Source : Human
Host : Escherichia Coli.
Form : The Peroxiredoxin solution contains 20 mM Tris-HCl pH-8, & 10% glycerol.
Purity : Greater than 90.0% as determined by SDS-PAGE.
Bio-activity : The specific activity was found to be approximately 200-230 pmole/min/µg. The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX2 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25°C for 1 minute.
Physical Appearance : Sterile Filtered colorless solution.
Amino acid sequence : MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN
Storage : PRDX2 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : PRDX2 peroxiredoxin 2 [ Homo sapiens ]
Official Symbol : PRDX2
Synonyms : PRDX2; peroxiredoxin 2; PRP; TSA; PRX2; TPX1; NKEFB; PRXII; TDPX1; MGC4104; peroxiredoxin-2; torin; NKEF-B; OTTHUMP00000165823; OTTHUMP00000165825; thioredoxin peroxidase 1; thiol-specific antioxidant 1; natural killer-enhancing factor B; thiol-specific antioxidant protein ;natural killer cell-enhancing factor B; thioredoxin-dependent peroxide reductase 1
Gene ID : 7001
mRNA Refseq : NM_005809
Protein Refseq : NP_005800
MIM : 600538
UniProt ID : P32119
Chromosome Location : 19p13
Pathway : Selenium Pathway
Function : antioxidant activity; oxidoreductase activity; thioredoxin peroxidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PRDX2 contribute to the field of cancer research and treatment? 04/25/2021

PRDX2's role in maintaining cellular redox balance implicates it in cancer progression. Modulating PRDX2 levels may offer avenues for developing novel cancer therapies.

Are there any side effects associated with targeting PRDX2 for therapeutic purposes? 02/11/2021

As with any targeted therapy, potential side effects need thorough investigation. Modulating PRDX2 levels could impact normal cellular functions, and careful assessment is required.

Is there evidence supporting the use of PRDX2 as a prognostic marker in certain diseases? 08/26/2020

Some studies suggest that PRDX2 levels may have prognostic value in diseases associated with oxidative stress, providing insights into disease progression.

Can PRDX2 be a target for drug development, and what challenges might be associated with this? 03/23/2018

Yes, PRDX2 is a potential drug target, but challenges include developing specific modulators and understanding the protein's complex regulatory mechanisms.

Are there any specific diagnostic tests or biomarkers related to PRDX2 protein levels? 08/22/2017

Research suggests that altered levels of PRDX2 could serve as a biomarker in diseases associated with oxidative stress, offering potential diagnostic applications.

Customer Reviews (3)

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Reviews
02/01/2022

    I am eager to embark on this scientific journey, empowered by the high-quality PRDX2 protein and the manufacturer's unparalleled assistance.

    12/16/2020

      The manufacturer's prompt and reliable technical support serves as an invaluable resource, reinforcing my confidence in the PRDX2 protein's effectiveness and enabling smooth progress in my experiments.

      11/01/2017

        Its remarkable purity and functional attributes make it an optimal choice for my research, ensuring accurate and reliable outcomes.

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