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Recombinant Human Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), His-tagged

Cat.No. : TGM2-1481H
Product Overview : Tissue Transglutaminase Human Recombinant produced in E.coli is a non-glycosylated, polypeptide chain having a molecular mass of 78,018 Dalton. tTG is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. By point mutation of the active center the catalytic transglutaminase activity has been eliminated, resulting in increased stability during storage and coating.
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Cat. No. : TGM2-1481H
Description : Tissue-type transglutaminase antigens have been specifically modified for improved handling: exchange of an active site amino acid eliminates the protein cross-linking activity of the enzyme, while maintaining the native three-dimensional structure and the enzyme"s secondary GTPase activity. This engineering assures reproducible properties of the antigen preparations through the absence of variable and ill-defined covalent aggregates of tTG antigen and host cell proteins.
Source : Human
Host : Escherichia Coli.
Form : TGM2 is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol.
Purity : Greater than 95.0% as determined by SDS-PAGE
Gene Name : TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [ Homo sapiens ]
Official Symbol : TGM2
Synonyms : TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); TG2; TGC; GNAH; G-ALPHA-h; Protein-glutamine gamma-glutamyltransferase 2; TG(C); Tissue transglutaminase; TGase C; Transglutaminase-2; TGase-H; EC 2.3.2.13; OTTHUMP00000030960; C polypeptide; transglutaminase 2; transglutaminase C
Gene ID : 7052
mRNA Refseq : NM_004613
Protein Refseq : NP_004604
MIM : 190196
UniProt ID : P21980
Chromosome Location : 20q12
Pathway : Huntington"s disease
Function : GTP binding; acyltransferase activity; calcium ion binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there diagnostic applications of TGM2 in clinical settings? 02/28/2021

TGM2 levels and activity can serve as diagnostic markers in certain conditions, providing insights into the progression and severity of diseases.

How does TGM2 influence cardiovascular health? 01/26/2021

TGM2 has been associated with cardiovascular diseases, contributing to the development of atherosclerosis and vascular calcification.

How does TGM2 contribute to fibrosis in organ tissues? 10/25/2020

TGM2 plays a role in fibrosis by promoting the cross-linking of extracellular matrix proteins, contributing to tissue stiffness and impaired organ function.

How does TGM2 affect inflammation and immune responses? 09/17/2020

TGM2 is involved in modulating inflammation and immune responses, influencing processes such as cytokine production and leukocyte adhesion.

Are there genetic mutations related to TGM2 that impact clinical outcomes? 07/08/2017

Genetic variations in TGM2 have been identified, and certain mutations may influence susceptibility to specific diseases or alter the enzyme's functionality.

Customer Reviews (3)

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Reviews
12/21/2020

    The TGM2 protein has demonstrated its efficacy in protein electron microscopy structure analysis.

    03/30/2020

      Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

      07/19/2018

        This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

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