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Recombinant Human Thrombopoietin

Cat.No. : THPO-1533H
Product Overview : Recombinant human rhTPO contains no μTagsμ and has a calculated MW of 37.4kDa. Asaresult of glycosylation, DTT-reduced protein migrates as a 60-80 kDa polypeptide in SDS-PAGE.
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Cat. No. : THPO-1533H
Description : Thrombopoietin (THPO) is a relatively lineage-specific cytokine that stimulates megakaryocyte growth and maturation in Thrombopoietin is a relatively lineage specific cytokine that stimulates megakaryocyte growth and maturation in vitro and is a potent in vivo thrombopoietic growth factor. On removal of the 21-amino acid signal peptide, the mature molecule consists of 2 domains: a receptor-binding domain that shows considerable homology to erythropoietin and a carbohydrate-rich carboxy-terminus of the protein that is highly glycosylated and important in maintaining protein stability.
Source : Recombinant human TPO/THPO (rhTPO) Met1-Gly349 (Accession AAI30323) was produced in human HEK293 cells.
Species : Human
Form : Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder Normally 5-8% trehalose and lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Purity : >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Endotoxin : Less than 1.0 EU per 1 μg of the rhTPO by the LAL method.
Storage : Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles.
Gene Name : THPO thrombopoietin [ Homo sapiens ]
Official Symbol : THPO
Synonyms : THPO; thrombopoietin; thrombopoietin nirs variant 1; megakaryocyte stimulating factor; MKCSF; c-mpl ligand; megakaryocyte colony-stimulating factor; MGDF; megakaryocyte growth and development factor; MPL ligand; myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGC163194; Myeloproliferative leukemia virus oncogene ligand; ML; TPO; MPLLG; OTTHUMP00000210502; OTTHUMP00000210503; OTTHUMP00000210504
Gene ID : 7066
mRNA Refseq : NM_000460
Protein Refseq : NP_000451
MIM : 600044
UniProt ID : P40225
Chromosome Location : 3q27
Pathway : Hematopoietic cell lineage; Formation of Platelet plug; Hemostasis; Platelet Activation; Platelet activation triggers
Function : cytokine activity; growth factor activity; hormone activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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