Rat Tnfa Crystal Structure
| Cat.No. : | Tnf-577R |
| Product Overview : | A DNA sequence encoding the mature form of rat Tnfμ ( P16599 ) ( Leu 80 - Leu 235 ) was expressed and purified, with an initial Met at the N-terminus. |
- Specification
- Gene Information
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| Cat. No. : | Tnf-577R |
| Description : | Tnf is the prototypic cytokine of the the Tnf superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. |
| Source : | Native |
| Host : | E. coli |
| Form : | Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
| Purity : | > 93 % as determined by SDS-PAGE |
| Endotoxin : | μ1.0 EU per μg protein as determined by the LAL method |
| Stability : | Samples are stable for up to twelve months from date of receipt at -70°C. |
| Predicted N terminal : | Met |
| Molecular Mass : | The recombinant rat Tnfμ consisting of 157 amino acids and has a calculated molecular mass of 17.4 kDa. It migrates as an approximately 15 kDa band in SDS-PAGE under reducing conditions. |
| Storage : | Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
| Gene Name : | Tnf tumor necrosis factor (TNF superfamily, member 2) [ Rattus norvegicus ] |
| Official Symbol : | Tnf |
| Synonyms : | Tnf; tumor necrosis factor (TNF superfamily, member 2); Tnfa; RATTNF; MGC124630; TNF-alpha; tumor necrosis factor; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor, alpha (cachetin); tumor necrosis factor superfamily member 2; tumor necrosis factor superfamily, member 2; tumor necrosis factor ligand superfamily member 2 |
| Gene ID : | 24835 |
| mRNA Refseq : | NM_012675 |
| Protein Refseq : | NP_036807 |
| UniProt ID : | TNFA_RAT |
| Chromosome Location : | 20p12 |
| Pathway : | Adipogenesis; Allograft rejection; Amoebiasis; Apoptosis; Asthema; Death Receptor Signalling; Influenza A; Leishmaniasis; Malaria; Osteoclast differentiation; Pertussis; Rheumatoid arthritis; Toxoplasmosis; Tuberculosis; Type I diabetes mellitus |
| Function : | Cytokine activity; identical protein binding; protease binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding |
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