Recombinant Human Sorbitol Dehydrogenase, His-tagged
Cat.No. : | SORD-2490H |
Product Overview : | Recombinant human SORD protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 40.4 kDa (377aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | SORD-2490H |
Description : | SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the zinc-dependent interconversion of polyols, such as sorbitol and xylitol, to their respective ketoses. |
Source : | E.coli. |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol. |
Purity : | > 90% by SDS – PAGE. |
Concentration : | 0.5 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPN E VLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVK HLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYK HNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPI GMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKP EVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIK GVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP. |
Storage : | can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | SORD sorbitol dehydrogenase [ Homo sapiens ] |
Synonyms : | sorbitol dehydrogenase; SORD1; SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; EC 1.1.1.14 |
Gene ID : | 6652 |
mRNA Refseq : | NM_003104 |
Protein Refseq : | NP_003095 |
MIM : | 182500 |
UniProt ID : | Q00796 |
Chromosome Location : | 15q15.3 |
Pathway : | Fructose and mannose metabolism; Metabolic pathways |
Function : | L-iditol 2-dehydrogenase activity; NAD or NADH binding; binding; metal ion binding; oxidoreductase activity; sugar binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
SORD-8575M | Recombinant Mouse SORD Protein, His (Fc)-Avi-tagged | +Inquiry |
SORD-4224R | Recombinant Rhesus Macaque SORD Protein, His (Fc)-Avi-tagged | +Inquiry |
Sord-6046M | Recombinant Mouse Sord Protein, Myc/DDK-tagged | +Inquiry |
SORD-701C | Recombinant Cynomolgus Monkey SORD Protein, His (Fc)-Avi-tagged | +Inquiry |
SORD-5330R | Recombinant Rat SORD Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SORD-1569HCL | Recombinant Human SORD 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionAt present, the association between SORD protein and disease is not well understood, and further research is needed to explore its role in specific diseases.
SORD protein is involved in the antioxidant process in cells, and may indirectly affect the antioxidant capacity in cells by regulating heptitol-6-phosphate metabolism.
There is no clear information on the association between SORD protein mutations and inherited diseases.
There is no evidence that the lack of SORD protein function directly leads to the development of disease. However, it may affect the normal function of the glucose metabolism pathway.
The protein may play a role in metabolic pathways related to metabolic diseases (e.g., diabetes mellitus and metabolic syndrome), but the specific relationship still needs to be further studied.
SORD protein is involved in the heptylol-6-phosphoreductase reaction in the glucose metabolism pathway, which converts heptitol-6-phosphate to cholesterol alcohol.
Customer Reviews (3)
Write a reviewThe stability of SORD products allows them to cope with different experimental conditions and modes of operation.
SORD has a high specific activity and can exert strong biological effects at low concentrations.
When experiments were performed with SORD, the reproducibility of the results was excellent.
Ask a Question for All SORD Products
Required fields are marked with *
My Review for All SORD Products
Required fields are marked with *
Inquiry Basket