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Recombinant Human Sorbitol Dehydrogenase, His-tagged

Cat.No. : SORD-2490H
Product Overview : Recombinant human SORD protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 40.4 kDa (377aa).
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Cat. No. : SORD-2490H
Description : SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the zinc-dependent interconversion of polyols, such as sorbitol and xylitol, to their respective ketoses.
Source : E.coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPN E VLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVK HLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYK HNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPI GMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKP EVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIK GVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP.
Storage : can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : SORD sorbitol dehydrogenase [ Homo sapiens ]
Synonyms : sorbitol dehydrogenase; SORD1; SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; EC 1.1.1.14
Gene ID : 6652
mRNA Refseq : NM_003104
Protein Refseq : NP_003095
MIM : 182500
UniProt ID : Q00796
Chromosome Location : 15q15.3
Pathway : Fructose and mannose metabolism; Metabolic pathways
Function : L-iditol 2-dehydrogenase activity; NAD or NADH binding; binding; metal ion binding; oxidoreductase activity; sugar binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What diseases are SORD proteins associated with? 09/22/2022

At present, the association between SORD protein and disease is not well understood, and further research is needed to explore its role in specific diseases.

How are SORD proteins related to antioxidants? 06/22/2022

SORD protein is involved in the antioxidant process in cells, and may indirectly affect the antioxidant capacity in cells by regulating heptitol-6-phosphate metabolism.

Are SORD protein mutations associated with genetic disorders? 06/14/2022

There is no clear information on the association between SORD protein mutations and inherited diseases.

Does the loss of function of the SORD protein lead to disease? 09/04/2021

There is no evidence that the lack of SORD protein function directly leads to the development of disease. However, it may affect the normal function of the glucose metabolism pathway.

How is SORD protein related to metabolic diseases? 12/07/2020

The protein may play a role in metabolic pathways related to metabolic diseases (e.g., diabetes mellitus and metabolic syndrome), but the specific relationship still needs to be further studied.

What is the function of SORD protein in the human body? 03/03/2020

SORD protein is involved in the heptylol-6-phosphoreductase reaction in the glucose metabolism pathway, which converts heptitol-6-phosphate to cholesterol alcohol.

Customer Reviews (3)

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Reviews
01/12/2023

    The stability of SORD products allows them to cope with different experimental conditions and modes of operation.

    12/03/2021

      SORD has a high specific activity and can exert strong biological effects at low concentrations.

      07/05/2021

        When experiments were performed with SORD, the reproducibility of the results was excellent.

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