Active Recombinant Rat Vascular Endothelial Growth Factor-165
Cat.No. : | Vegfa-586R |
Product Overview : | Recombinant rat VEGF is a disulfide linked polypeptide containing two 165 amino acids peptides that total to a size of 38,750 Da. |
- Specification
- Gene Information
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Cat. No. : | Vegfa-586R |
Description : | Vascular Endothelial Growth Factor (VEGF) is an important cytokine involved in growth, angiogenesis and vascular permeability. It is produced by cells under hypoxic conditions or by cells exposed to cytokines such as IL-1, IL-6, IL-8 or TNF-μ. VEGF predominantly signals through type I transmembrane receptor tyrosine kinases, VEGF R1 (also called flt-1) and the VEGF R2 (also called Flk-1/KDR). VEGF retains high sequence identity between most mammals. |
Species : | Rat |
Source : | E.coli |
Form : | Lyopohilized from 10 mM NaP, pH 7.5. |
Purity : | Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
Bio-activity : | As determined by the dose-dependent induced proliferation of Human umbilical vein endothelial cells (HUVECs) when compared to a standard. The expected ED50 is 4.0-8.0 ng/ml. |
Physical Appearance : | Sterile Filtered white lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
Purity Greater than 97% as determined by : | Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
Protein Content determined by : | UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
Endotoxin Level : | Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug. |
Amino acid sequence : | MAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR |
Storage : | Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage. |
Gene Name : | Vegfa vascular endothelial growth factor A [ Rattus norvegicus ] |
Official Symbol : | Vegfa |
Synonyms : | Vegfa; vascular endothelial growth factor A; Vegf; VEGF164; VPF; VEGF-A; vascular permeability factor |
Gene ID : | 83785 |
mRNA Refseq : | NM_001110333 |
Protein Refseq : | NP_001103803 |
UniProt ID : | B5DEK7 |
Pathway : | Bladder cancer; Endochondral Ossification; Focal adhesion; Formation of Platelet plug; Hemostasis; Hypertrophy Mode; Id Signaling Pathway; Pancreatic cancer; Pathways in cancer; Platelet Activation; Renal cell carcinoma |
Function : | cell surface binding; chemoattractant activity; cytokine activity; fibronectin binding; growth factor activity; heparin binding; platelet-derived growth factor receptor binding; protein homodimerization activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding |
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◆ Native Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have shown that there is an association between the expression level of VEGFA protein and other biomarkers, for example, it can be associated with indicators such as tumor cell differentiation, metastatic capacity, and prognosis.
At present, a variety of drugs have been developed to target the VEGFA protein and its related signaling pathway, including inhibiting its expression and inhibiting its binding to receptors, etc., for the treatment of tumors and other vascular-related diseases.
VEGFA protein plays a key role in tumor angiogenesis, promoting tumor growth and metastasis by stimulating endothelial cell proliferation, migration, and vascular network formation.
The expression of VEGFA protein in different tissues and organs is different, and it is expressed in tumor tissue, cardiovascular system and other tissues and organs, and the expression level may be affected by many factors.
Studies have shown that the expression level of VEGFA protein is related to the degree of malignancy of the tumor, and the high expression of VEGFA protein often indicates that the tumor is more aggressive.
VEGFA protein plays an important role in cardiovascular disease by regulating endothelial cell function, promoting vascular repair and maintaining cardiovascular system homeostasis.
Customer Reviews (2)
Write a reviewVEGFA's catalytic activity is so strong that it can adapt even in the face of complex chemical reactions.
VEGFA they produced was highly active and the experimental effect was obvious.
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