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Recombinant Human AGER, His-tagged

Cat.No. : AGER-3648H
Product Overview : Total 339 AA. MW: 36.5 kDa. N-Terminal His-tag 14 AA (highlighted).
  • Specification
  • Gene Information
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Cat. No. : AGER-3648H
Description : RAGE, the Receptor for Advanced Glycation Endproducts is a 35kD transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. It is also called AGER.
Source : E. coli
Species : Human
Form : Filtered (0.4 um) and lyophilized in 0.5 mg/ml in 0.03 M Acetate buffer, pH 4.
Research topic : Diabetology - Other Relevant Products, Neural tissue damage markers, Renal disease.
Purity : >95%
Reconstitution : Add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications : Western blotting
Quality Control Test : BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
Sequences of amino acids : MRGSHHHHHH GMASAQNITA RIGEPLVLKC KGAPKKPPQR LEWKLNTGRT EAWKVLSPQG GGPWDSVARV LPNGSLFLPA VGIQDEGIFR CQAMNRNGKE TKSNYRVRVY QIPGKPEIVD SASELTAGVP NKVGTCVSEG SYPAGTLSWH LDGKPLVPNE KGVSVKEQTR RHPETGLFTL QSELMVTPAR GGDPRPTFSC SFSPGLPRHR ALRTAPIQPR VWEPVPLEEV QLVVEPEGGA VAPGGTVTLT CEVPAQPSPQ IHWMKDGVPL PLPPSPVLIL PEIGPQDQGT YSCVATHSSH GPQESRAVSI SIIEPGEEGP TAGEGFDKVR EAEDSPQHM
Storage : Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Gene Name : AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
Official Symbol : AGER
Synonyms : AGER; advanced glycosylation end product-specific receptor; RAGE; MGC22357; OTTHUMP00000029155; OTTHUMP00000029156; OTTHUMP00000029157; OTTHUMP00000029158; OTTHUMP00000174885; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; RAGE isoform delta; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; receptor for advanced glycosylation end-products
Gene ID : 177
mRNA Refseq : NM_001136
Protein Refseq : NP_001127
MIM : 600201
Uniprot ID : Q15109
Chromosome Location : 6p21.3
Function : S100 alpha binding; advanced glycation end-product receptor activity; protein binding; receptor activity; transmembrane receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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How does AGER affect bone health? 09/02/2022

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER? 08/10/2022

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs? 07/05/2022

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging? 05/30/2022

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein? 07/15/2021

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation? 07/15/2021

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing? 02/05/2021

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases? 01/22/2021

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function? 12/06/2020

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs? 09/23/2020

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health? 01/31/2020

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER? 06/09/2019

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications? 05/13/2019

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research? 01/28/2019

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein? 07/25/2018

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects? 10/05/2017

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses? 06/29/2017

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health? 12/04/2016

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein? 11/25/2016

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing? 11/02/2016

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.

Customer Reviews (5)

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Reviews
02/26/2022

    It's quality was evident in consistent results across replicates.

    08/13/2021

       Protein consistently upregulated the expression of tissue-specific markers.

      01/20/2020

         Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

        06/22/2019

          It’s consistent outcomes supported reliable statistical analysis.

          01/11/2017

            Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

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