Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CLCF1, His-tagged

Cat.No. : CLCF1-3626H
Product Overview : Recombinant human CLCF1 protein, fused to His-tag at N-terminus, was expressed in E.coli (28-225aa).
  • Specification
  • Gene Information
  • Related Products
Cat. No. : CLCF1-3626H
Description : CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.
Form : Liquid. 20mM sodium citrate (pH 3.5), 0.4M Urea, 10% glycerol
Molecular Weight : 24.6 kDa (219aa)
Purity : > 90% by SDS - PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Gene Name : CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens ]
Official Symbol : CLCF1
Synonyms : CLCF1; cardiotrophin-like cytokine factor 1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; B cell-stimulating factor 3; cold-induced sweating syndrome 2
Gene ID : 23529
mRNA Refseq : NM_001166212
Protein Refseq : NP_001159684
MIM : 607672
UniProt ID : Q9UBD9
Chromosome Location : 11q13.3
Function : cytokine activity; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can CLCF1 be measured as a biomarker for certain diseases? 07/22/2021

Research suggests that levels of CLCF1 in blood or tissues may serve as potential biomarkers for specific diseases, aiding in early diagnosis and prognosis.

How is CLCF1 production regulated in the human body? 09/05/2020

The production of CLCF1 is tightly regulated at the transcriptional and post-translational levels, involving various signaling pathways.

Are there any clinical trials exploring the use of CLCF1 in medical interventions? 12/04/2018

Yes, there are ongoing clinical trials investigating the therapeutic potential of CLCF1 in various diseases, including autoimmune disorders and neurodegenerative conditions.

How does CLCF1 interact with other cytokines in the IL-6 family? 08/17/2018

CLCF1 can interact with various receptors and signaling molecules within the IL-6 cytokine family, influencing a range of physiological processes.

In what ways does CLCF1 contribute to neurodegenerative disorders? 10/19/2017

Studies have indicated that CLCF1 may play a role in neurodegenerative conditions, and understanding its function could lead to potential therapies for diseases like Alzheimer's and Parkinson's.

Customer Reviews (3)

Write a review
Reviews
10/25/2019

    With their meticulous documentation and support, I am confident that my utilization of CLCF1 protein in clinical trials will meet all necessary regulations and guidelines.

    05/07/2017

      the manufacturer's supply management capabilities assure a seamless and continuous provision of the CLCF1 protein.

      09/19/2016

        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

        Ask a Question for All CLCF1 Products

        Required fields are marked with *

        My Review for All CLCF1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends