Recombinant Human CLCF1, His-tagged
Cat.No. : | CLCF1-3626H |
Product Overview : | Recombinant human CLCF1 protein, fused to His-tag at N-terminus, was expressed in E.coli (28-225aa). |
- Specification
- Gene Information
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Cat. No. : | CLCF1-3626H |
Description : | CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. |
Form : | Liquid. 20mM sodium citrate (pH 3.5), 0.4M Urea, 10% glycerol |
Molecular Weight : | 24.6 kDa (219aa) |
Purity : | > 90% by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
Gene Name : | CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens ] |
Official Symbol : | CLCF1 |
Synonyms : | CLCF1; cardiotrophin-like cytokine factor 1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; B cell-stimulating factor 3; cold-induced sweating syndrome 2 |
Gene ID : | 23529 |
mRNA Refseq : | NM_001166212 |
Protein Refseq : | NP_001159684 |
MIM : | 607672 |
UniProt ID : | Q9UBD9 |
Chromosome Location : | 11q13.3 |
Function : | cytokine activity; growth factor activity |
Products Types
◆ Recombinant Protein | ||
Clcf1-2178M | Recombinant Mouse Clcf1 Protein, Myc/DDK-tagged | +Inquiry |
Clcf1-619M | Recombinant Mouse Clcf1 Protein, His-tagged | +Inquiry |
CLCF1-1716M | Recombinant Mouse CLCF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CLCF1-618H | Recombinant Human CLCF1 Protein, His-tagged | +Inquiry |
CLCF1-3242H | Recombinant Human CLCF1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
CLCF1-001HCL | Recombinant Human CLCF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResearch suggests that levels of CLCF1 in blood or tissues may serve as potential biomarkers for specific diseases, aiding in early diagnosis and prognosis.
The production of CLCF1 is tightly regulated at the transcriptional and post-translational levels, involving various signaling pathways.
Yes, there are ongoing clinical trials investigating the therapeutic potential of CLCF1 in various diseases, including autoimmune disorders and neurodegenerative conditions.
CLCF1 can interact with various receptors and signaling molecules within the IL-6 cytokine family, influencing a range of physiological processes.
Studies have indicated that CLCF1 may play a role in neurodegenerative conditions, and understanding its function could lead to potential therapies for diseases like Alzheimer's and Parkinson's.
Customer Reviews (3)
Write a reviewWith their meticulous documentation and support, I am confident that my utilization of CLCF1 protein in clinical trials will meet all necessary regulations and guidelines.
the manufacturer's supply management capabilities assure a seamless and continuous provision of the CLCF1 protein.
In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.
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