Recombinant Human GRHPR, His-tagged

• Cat.No.: GRHPR-2491H
• Product Overview: Recombinant human GRHPR protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 37.8 kDa (348aa).

Specification

• Cat. No.: GRHPR-2491H
• Description: GRHPR, also known as GLXR, is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. Localizing to the cytosol, GRHPR is ubiquitously expressed with highest expression levels found in liver. The protein has widespread tissue expression and has a role in metabolism. GRHPR is an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities.
• Source: E.coli.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL.
• Storage: can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GRHPR glyoxylate reductase/hydroxypyruvate reductase [ Homo sapiens ]
• Synonyms: glyoxylate reductase/hydroxypyruvate reductase; PH2; GLXR; GLYD; GRHPR; glyoxylate reductase/hydroxypyruvate reductase; glycerate-2-dehydrogenase; EC 1.1.1.79
• Gene ID: 9380
• mRNA Refseq: NM_012203
• Protein Refseq: NP_036335
• MIM: 604296
• UniProt ID: Q9UBQ7
• Chromosome Location: 9q12
• Pathway: Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Pyruvate metabolism
• Function: NAD or NADH binding; cofactor binding; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; oxidoreductase activity; protein binding