Monoclonal Anti-human CD40
CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes,dendritic cells,and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily,which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L,CD154,gp39,and TRAM) belongs to the TNF gene family and is expressed more widely than CD40,predominantly on activated CD4+T cells. Following interaction with CD40 ligand,CD40 mediates a number of major immunoregulatory functions,central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion,proliferation,immunoglobulin isotype switch,and secretion.
anti-μ activated tonsillar human B cells
QMA Hyper D ion exchange chromatography
This monoclonal antibody may be used between 1-10 μg/ml. 10ng/ml for cellular activation. Optimal dilution should be determined by each laboratory for each application. Coupled antibody: to maintain RT before use.
-20 °C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.