Mouse Anti-Human CD40 Monoclonal Antibody

• Cat.No.: DMAB6033MH
• Product Overview: Monoclonal Anti-human CD40

Specification

• Antigen Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes,dendritic cells,and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily,which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L,CD154,gp39,and TRAM) belongs to the TNF gene family and is expressed more widely than CD40,predominantly on activated CD4+T cells. Following interaction with CD40 ligand,CD40 mediates a number of major immunoregulatory functions,central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion,proliferation,immunoglobulin isotype switch,and secretion.
• specificity: human CD40
• Target: CD40
• Immunogen: anti-μ activated tonsillar human B cells
• Host: Mouse
• Isotype: IgG1
• species: Human
• Clone: nBc 90
• Purification: QMA Hyper D ion exchange chromatography
• Applications: N/A
• Usage recommendation: This monoclonal antibody may be used between 1-10 μg/ml. 10ng/ml for cellular activation. Optimal dilution should be determined by each laboratory for each application. Coupled antibody: to maintain RT before use.
• Storage: -20 °C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.

Gene Information

• Gene Name: CD40 CD40 molecule,TNF receptor superfamily member 5 [ Homo sapiens ]
• Official Symbol: CD40
• Synonyms: CD40;p50;Bp50;CDW40;TNFRSF5;tumor necrosis factor receptor superfamily member 5;CD40L receptor;CD40 type II isoform;B cell-associated molecule;B cell surface antigen CD40;B-cell surface antigen CD40;CD40 antigen (TNF receptor superfamily member 5);tumor n
• Gene ID: 958
• mRNA Refseq: NM_001250
• Protein Refseq: NP_001241
• MIM: 109535
• UniProt ID: P25942
• Chromosome Location: 20q12-q13.2
• Pathway: Adaptive Immune System;Allograft rejection;Asthma;Autoimmune thyroid disease;CD40/CD40L signaling;Cell adhesion molecules (CAMs);Cytokine-cytokine receptor interaction
• Function: enzyme binding;protein binding;receptor activity;signal transducer activity