Mouse Anti-Human MAT2A Monoclonal Antibody

• Cat.No.: DMAB9748MH
• Product Overview: Monoclonal Antibody to MAT2A.

Specification

• Antigen Description: MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver,MAT2A expression associates with growth,dedifferentiation,and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
• Target: MAT2A
• Immunogen: Anti-human MAT2A mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human MAT2A amino acids 1-395 purified from E. coli.
• Host: Mouse
• Isotype: Mouse IgG2b heavy chain and κ light chain.
• species: Human
• Clone: QBU4B3BU
• Purification: MAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Applications: ELISA,WB,IHC
• Concentration: 1mg/ml containing PBS,pH-7.4,& 0.1% Sodium Azide.
• Storage: Stable for 1 year at -20 °C and 3 months at 4 °C. For maximum recovery of the product,centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: MAT2A methionine adenosyltransferase II,alpha [ Homo sapiens ]
• Official Symbol: MAT2A
• Synonyms: MAT2A;methionine adenosyltransferase II,alpha;MATA2;MATII;SAMS2;S-adenosylmethionine synthase isoform type-2;MAT 2;MAT-II;adoMet synthase 2;adoMet synthetase 2;methionine adenosyltransferase 2;EC 2.5.1.6;AdoMet synthase 2;Methionine adenosyltransferase 2
• Gene ID: 4144
• mRNA Refseq: NM_005911
• Protein Refseq: NP_005902
• MIM: 601468
• UniProt ID: P31153
• Chromosome Location: 2p11.2
• Pathway: Biological oxidations;C-MYB transcription factor network;Cysteine and methionine metabolism;Metabolic pathways;Metabolism;Metabolism of amino acids and derivatives;Methionine degradation
• Function: ATP binding;metal ion binding;methionine adenosyltransferase activity;nucleotide binding;transferase activity