Recombinant Human Chloride Intracellular Channel 1, His-tagged
Cat.No. : | CLIC1-2498H |
Product Overview : | Recombinant human CLIC1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 29.0 kDa (261aa). |
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- Gene Information
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Cat. No. : | CLIC1-2498H |
Description : | CLIC1 (Chloride intracellular channel 1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. This protein is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as an anion-selective channel. It forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. |
Source : | E.coli. |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl. |
Purity : | > 90% by SDS – PAGE. |
Concentration : | 1.0 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K. |
Storage : | can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | CLIC1 chloride intracellular channel 1 [ Homo sapiens ] |
Synonyms : | chloride intracellular channel 1; G6; NCC27; CLIC1; chloride intracellular channel protein 1; hRNCC; p64CLCP; RNCC protein; OTTHUMP00000029133; OTTHUMP00000029137; OTTHUMP00000174486; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein;Chloride channel ABP; Nuclear chloride ion channel 27; Regulatory nuclear chloride ion channel protein |
Gene ID : | 1192 |
mRNA Refseq : | NM_001288 |
Protein Refseq : | NP_001279 |
MIM : | 602872 |
UniProt ID : | O00299 |
Chromosome Location : | 6p22.1-p21.2 |
Function : | chloride channel activity; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity |
Products Types
◆ Recombinant Protein | ||
CLIC1-1477H | Recombinant Human CLIC1 Protein, GST-tagged | +Inquiry |
CLIC1-1106R | Recombinant Rat CLIC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Clic1-519M | Recombinant Mouse Clic1 Protein, MYC/DDK-tagged | +Inquiry |
CLIC1-620H | Recombinant Human CLIC1 Protein, His-tagged | +Inquiry |
CLIC1-27816TH | Recombinant Human CLIC1, His-tagged | +Inquiry |
◆ Lysates | ||
CLIC1-7448HCL | Recombinant Human CLIC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.
Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.
CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.
Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.
CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.
Customer Reviews (3)
Write a reviewWith the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.
Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.
Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.
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