HTLV-1 is the etiological agent for Adult T-Cell Leukemia which encodes a 40kDa cell-transforming oncoprotein called Tax. HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents. Constitutive Activation of TAK1 by HTLV-1 Tax-dependent Overexpression of TAB2 Induces Activation of JNK-ATF2 but Not IKK-NF-kB.
r.HTLV TAX protein.
Ion exchange column.
1mg/ml in PBS (after reconstitution).
By direct ELISA (against recombinant gp24), 1:50,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).
Direct ELISA, Western Blot, Immunoprecipitation.
Antibody is shipped lyophilized at ambient temperature.
Stability / Shelf Life:
Two years lyophilized, one month in solution at 4°C.
Reconstitute with H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.