| Cat. No. | CABT-21842MH |
| Antigen Description | Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. |
| Product Overview | Mouse monoclonal antibody raised against a partial recombinant CBY1. |
| Immunogen | CBY1 (NP_056188, 18 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Isotype | IgG1 Kappa |
| Application | Western Blot, Sandwich ELISA |
| Storage Buffer | In 1x PBS, pH 7.2 |
| Storage Instruction | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Sequence | SASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK* |
| Reactivity | Human |
| Clone | 3G3 |
| Host | Mouse |
| Antigen Gene Information | Gene Name | CBY1 chibby homolog 1 (Drosophila) [Homo sapiens] |
| Official symbol | CBY1 |
| Synonyms | chibby homolog 1 (Drosophila); Cby; PIGEA-14; Chibby; C22orf2; chromosome 22 open reading frame 2; OTTHUMP00000198876; PIGEA14; OTTHUMP00000198878; PKD2 interactor, golgi and endoplasmic reticulum associated 1; arb1; Cytosolic leucine-rich protein; coiled-coil protein PIGEA-14; PGEA1; polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein,14 kDa; ARPP-binding protein; protein chibby homolog 1; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; HS508I15A; OTTHUMP00000198875; polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa |
| GeneId | 25776 |
| mRNA Refseq | NM_001002880 |
| Protein Refseq | NP_001002880 |
| MIM | 607757 |
| Uniprot ID | Q9Y3M2 |
| Chromosome Location | 22q12 |
| Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem |
| Function | beta-catenin binding; identical protein binding; protein binding |
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