Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Native Human MUC16 Protein

Cat.No. : CDA002
Product Overview : Native Human MUC16 Protein was purified from Human Ascites Fluid.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.
Source : Human Ascites Fluid
Species : Human
Form : Solution in phosphate buffered saline pH 7.4 with 3% sucrose and 0.05% sodium azide.
Bio-activity : > 100 kU/mL (EIA)
Purity : > 95% (SDS-PAGE)
Storage : Store at -20 centigrade
Gene Name : MUC16 mucin 16, cell surface associated [ Homo sapiens ]
Official Symbol : MUC16
Synonyms : MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;
Gene ID : 94025
mRNA Refseq : NM_024690
Protein Refseq : NP_078966
MIM : 606154
UniProt ID : Q8WXI7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does MUC16 interact with other components of the epithelial barrier and immune system? 10/15/2022

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier? 10/12/2022

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment? 08/02/2021

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases? 03/15/2021

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function? 05/03/2020

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer? 02/15/2018

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development? 04/03/2017

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.

Customer Reviews (3)

Write a review
Reviews
07/28/2020

    Critical for decision-making. Supports our research endeavors.

    05/24/2018

      Expert service quality. Valuable for research integrity.

      06/05/2017

        Dependable partner in experiments. Consistent and trustworthy.

        Ask a Question for All MUC16 Products

        Required fields are marked with *

        My Review for All MUC16 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends