Native Human Apolipoprotein CII

• Cat.No.: APOC2-4904H
• Product Overview: Native Human Apolipoprotein CII was purified from Human Plasma.

Specification

• Description: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
• Source: Human Plasma
• Species: Human
• Form: Lyophilized from 10 mM NH4HCO3, pH 7.4
• Molecular Mass: 8800
• Purity: >=95% by SDS-PAGE
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: > 1 Year
• Storage: -20°C

Gene Information

• Gene Name: APOC2 apolipoprotein C-II [ Homo sapiens (human) ]
• Official Symbol: APOC2
• Synonyms: APOC2;apolipoprotein C-II; APO-CII; APOC-II; MGC75082; apolipoprotein C2; apoC-II; Apolipoprotein C2; APC2; Apo-CII; apo-CII; ApoC-II
• Gene ID: 344
• mRNA Refseq: NM_000483
• Protein Refseq: NP_000474
• MIM: 608083
• UniProt ID: P02655
• Chromosome Location: 19q13.2
• Pathway: Chylomicron-mediated lipid transport; HDL-mediated lipid transport; Lipid digestion; Lipoprotein metabolism; Metabolism of lipids and lipoproteins; Statin Pathway
• Function: enzyme activator activity; lipase inhibitor activity; lipid binding; lipoprotein lipase activator activity; phospholipase activator activity; phospholipase binding; protein homodimerization activity