Recombinant Human Caspase 1, Apoptosis-Related Cysteine Peptidase (interleukin 1, beta, convertase), His-tagged
Cat.No. : | CASP1-1639H |
Product Overview : | Recombinant active human CASP1 containing N-term His-tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CASP1-1639H |
Description : | CASP1 (also know as ICE) is a prototypical member of the caspase-family of cysteine proteases. CASP1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kD) and small (10 kD) subunits. The active CASP1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of CASP1 activation and the role of CASP1 in apoptosis are poorly understood. |
Biological Activity : | > 5000 units/mg |
Molecular Weight : | large (20 kD) and small (10 kD) subunitsk |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized powder. |
Appearance : | Lyophilized powder |
Reconstitution : | Reconstitute to 1 unit per µl in PBS containing 15% glycerol. |
Storage : | The lyophilized CASP1 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease. |
Pathways : | Amyotrophic lateral sclerosis (ALS); Androgen Receptor Signaling Pathway; Apoptosis; Caspase cascade in apoptosis; Cellular roles of Anthrax toxin; Cytokine Signaling in Immune system; Cytosolic DNA-sensing pathway; Direct p53 effectors; IFN-gamma pathway; IL1-mediated signaling events; Immune System; Inflammasomes; Influenza A; Innate Immunity Signaling; Interleukin-1 processing |
Gene Name : | CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) [ Homo sapiens ] |
Official Symbol : | CASP1 |
Synonyms : | CASP1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); ICE; P45; IL1BC; caspase-1; IL-1BC; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1-B converting enzyme; Caspase-1; CASP-1; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; EC 3.4.22.36; OTTHUMP00000045728; OTTHUMP00000232029; OTTHUMP00000232030; OTTHUMP00000232031; OTTHUMP00000232032; OTTHUMP00000232033; OTTHUMP00000232034; OTTHUMP00000232036 |
Gene ID : | 834 |
mRNA Refseq : | NM_033292 |
Protein Refseq : | NP_150634 |
MIM : | 147678 |
UniProt ID : | P29466 |
Chromosome Location : | 11q23 |
Function : | cysteine-type endopeptidase activity; caspase activator activity; peptidase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
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CASP1-1265H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), Tag Free | +Inquiry |
Casp1-0413M | Active Recombinant Mouse Casp1 Protein | +Inquiry |
CASP1-1266H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), His tagged | +Inquiry |
CASP1-1240M | Recombinant Mouse CASP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CASP1-7840HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
CASP1-7841HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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