Recombinant Human CXCL5 protein
Cat.No. : | CXCL5-12H |
Product Overview : | Recombinant Human CXCL5 protein (5-78 a.a.) was expressed in Escherichia coli. |
- Specification
- Gene Information
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Description : | CXCL5 is a small cytokine also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). The gene for human CXCL5 is encoded by four exons which belong to CXCL5 gene located on human chromosome 4. The protein is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. In vitro, ENA-78 (8-78) and ENA-78 (9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. They are produced by proteolytic cleavage after secretion from peripheral blood monocytes. Recombinant human CXCL5 (5-78 a.a.) contains 74 amino acids and it is a single non-glycosylated polypeptide chain. Human CXCL5 shares 57 % amino acid sequence identity with mouse and rat CXCL5. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB, pH 7.4, 50 mM NaCl. |
Bio-activity : | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 5.0-10 ng/ml. |
Molecular Mass : | Approximately 8.1 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids. |
Protein length : | 74 |
AA Sequence : | AAVLRELRCVCLQTTQGVHPKMISN LQVFAIGPQCSKVEVVASLKNGKEI CLDPEAPFLKKVIQKILDGGNKEN |
Endotoxin : | Less than 1 EU/μg of rHuENA-78, 5-78a.a./CXCL5 as determined by LAL method. |
Purity : | >97% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | CXCL5 |
Official Symbol : | CXCL5 |
Synonyms : | CXCL5; chemokine (C-X-C motif) ligand 5; SCYB5, small inducible cytokine subfamily B (Cys X Cys), member 5 (epithelial derived neutrophil activating peptide 78); C-X-C motif chemokine 5; ENA 78; ENA-78(1-78); small inducible cytokine B5; small-inducible cytokine B5; neutrophil-activating protein 78; neutrophil-activating peptide ENA-78; epithelial-derived neutrophil activating protein 78; epithelial-derived neutrophil-activating peptide 78; epithelial-derived neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); SCYB5; ENA-78; |
Gene ID : | 6374 |
mRNA Refseq : | NM_002994 |
Protein Refseq : | NP_002985 |
MIM : | 600324 |
UniProt ID : | P42830 |
Products Types
◆ Recombinant Protein | ||
CXCL5-692H | Recombinant Human CXCL5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CXCL5-424C | Active Recombinant Human CXCL5 Protein (9-78, 70 aa) | +Inquiry |
CXCL5-01C | Recombinant Cynomolgus CXCL5 Protein | +Inquiry |
CXCL5-272H | Active Recombinant Human CXCL5 Protein (Arg45-Asn114), N-His tagged, Animal-free, Carrier-free | +Inquiry |
Cxcl5-227C | Active Recombinant Rat Cxcl5 Protein (88 aa) | +Inquiry |
◆ Lysates | ||
CXCL5-7167HCL | Recombinant Human CXCL5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCXCL5 is implicated in promoting tumor growth and metastasis by facilitating the migration of cancer cells and modulating the tumor microenvironment.
Several clinical trials are exploring the efficacy of drugs that modulate CXCL5 levels in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
CXCL5 has been identified as a regulator of angiogenesis, influencing the formation of new blood vessels, a process crucial for tumor growth and wound healing.
CXCL5's role in recruiting cells to damaged tissues makes it a potential candidate for enhancing regenerative medicine approaches, such as tissue repair and wound healing.
CXCL5 levels can be measured in blood or tissue samples to assess the extent of inflammation, aiding in the diagnosis and monitoring of various diseases.
Customer Reviews (3)
Write a reviewIts versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.
Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.
The CXCL5 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.
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