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Cat. No.
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ACVR1-984H
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Product Overview
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Recombinant human ACVR1
(147-end) was expressed by baculovirus in Sf9 insect cells using an
N-terminal GST tag.
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Description
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ACVR1 is a receptor
serine/threonine kinase that is member of the ACVR family and is upstream of
signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown
of ACVR1, but not TGFβRI (ACVR1), abrogates endoglin-mediated decrease in
cell motility of prostate cancer cells and constitutively active ACVR1 is sufficient
to restore a low-motility phenotype in endoglin deficient cells. Therefore,
endoglin decreases prostate cancer cell motility through activation of the ACVR-Smad1
pathway. ACVR1 is the key gene involved in Fibrodysplasia ossificans
progressiva (FOP), a rare autosomal dominant congenital disorder
characterized by progressive heterotopic bone formation in muscle tissues.
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Applications
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Kinase Assay;
Western Blot
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Molecular Weight
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67 kDa
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Expression System
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Sf9 insect cells using baculovirus
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Species
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Human
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Form
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Recombinant protein
stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM
EDTA, 0.1 mM PMSF, 25 % glycerol.
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Specific Activity
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46 nmol/min/mg
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Purity
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>
90 %
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Concentration
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0.1 ug/ul
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Sequences
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147-end
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Storage
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Store
product at -70oC. For optimal
storage, aliquot target into smaller quantities after centrifugation and
store at recommended temperature. For most favorable performance, avoid
repeated handling and multiple freeze/thaw cycles.
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Antigen Gene Information
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Gene Name
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ACVR1 activin A receptor, type I [ Homo
sapiens ]
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Official Symbol
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ACVR1
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Synonyms
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ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI;
ACTRI; ACVR1A; ACVRLK2; activin receptor type-1; activin receptor type I;
hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B
superfamily receptor type I; activin A receptor, type II-like kinase 2;
serine/threonine-protein kinase receptor R1; Activin receptor type-1; EC 2.7.11.30; Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase
receptor R1; TGF-B superfamily receptor type I; TSR-I; OTTHUMP00000162806;
OTTHUMP00000204626; OTTHUMP00000240120
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GeneID
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90
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mRNA Refseq
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NM_001105
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Protein Refseq
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NP_001096
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MIM
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102576
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UniProt ID
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Q04771
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Chromosome Location
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2q23-q24
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Pathways
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ALK1
pathway; ALK1 signaling events; ALK2 signaling events; Cytokine-cytokine
receptor interaction; TGF-beta signaling pathway
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Function
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ATP
binding; SMAD binding; activin binding; contributes_to activin receptor
activity, type I; follistatin binding; metal ion binding; nucleotide binding;
protein binding; protein homodimerization activity; protein serine/threonine
kinase activity; receptor activity; receptor signaling protein
serine/threonine kinase activity; transforming growth factor beta binding; transforming
growth factor beta receptor activity, type I; transmembrane receptor protein
serine/threonine kinase activity
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.jpg)
Protein ACVR1 PDB 3H9R.
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Download Datasheet:
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