| Cat. No. : |
BMPR1A-991H |
| Description : |
BMPR1A (also known as bone morphogenetic protein receptor 1A) is a member of the transmembrane serine/threonine kinase family that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A act as a minor susceptibility gene for PTEN-mutation-negative Cowden syndrome. BMPR1A regulates the PTEN protein levels by decreasing PTEN"s association with the degradative pathway. BMPR1A trafficking plays a significant role in FOP pathogenesis and is also involved in human T-cell differentiation. |
| Applications : |
Kinase Assay; Western Blot |
| Molecular Weight : |
66 kDa |
| Expression System : |
Sf9 insect cells using baculovirus |
| Species : |
Human |
| Form : |
Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Specific Activity : |
1.2 nmol/min/mg |
| Purity : |
> 90 % |
| Concentration : |
0.1 ug/ul |
| Sequences : |
187-end |
| Storage : |
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : |
Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP; Endochondral Ossification; Heart Development |
