Recombinant Human Doublecortin-like Kinase 1, GST-tagged
Cat.No. : | DCLK1-1009H |
Product Overview : | Full-length recombinant human DCLK1 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. |
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Cat. No. : | DCLK1-1009H |
Description : | DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCLK1 is a microtubule-associated kinase that can undergo autophosphorylation. DCLK1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCLK1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 110 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
Specific Activity : | 3.4 nmol/min/mg |
Purity : | > 85 % |
Concentration : | 0.1 ug/ul |
Sequences : | Full length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | DCLK1 doublecortin-like kinase 1 [ Homo sapiens ] |
Official Symbol : | DCLK1 |
Synonyms : | DCLK1; doublecortin-like kinase 1; CL1; DCLK; CLICK1; DCDC3A; DCAMKL1; KIAA0369; serine/threonine-protein kinase DCLK1; OTTHUMP00000018250; OTTHUMP00000018251; OTTHUMP00000018252; doublecortin and CaM kinase-like 1; doublecortin-like and CAM kinase-like 1; doublecortin domain-containing protein 3A; EC=2.7.11.1 |
Gene ID : | 9201 |
mRNA Refseq : | NM_004734 |
Protein Refseq : | NP_004725 |
MIM : | 604742 |
UniProt ID : | O15075 |
Chromosome Location : | 13q13.3 |
Function : | ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein activity |
Products Types
◆ Recombinant Protein | ||
DCLK1-2383H | Recombinant Human DCLK1 Protein, GST-tagged | +Inquiry |
DCLK1-211H | Recombinant Human DCLK1 Protein, His-tagged | +Inquiry |
DCLK1-01H | Recombinant Human DCLK1 Protein, His-tagged | +Inquiry |
Dclk1-2473M | Recombinant Mouse Dclk1 Protein, Myc/DDK-tagged | +Inquiry |
DCLK1-0862H | Recombinant Human DCLK1 Protein (S2-F740), Tag Free | +Inquiry |
◆ Lysates | ||
DCLK1-435HCL | Recombinant Human DCLK1 cell lysate | +Inquiry |
DCLK1-001HCL | Recombinant Human DCLK1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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