Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog, GST-tagged

• Cat.No.: FOS-4846H
• Product Overview: Recombinant full-length human FOS was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: FOS-4846H
• Description: FOS is a member of the FOS gene family that consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. FOS gene encodes a leucine zipper protein that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 78 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: > 90%
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: B cell receptor signaling pathway; ATF-2 transcription factor network; Activated TLR4 signalling; Activation of the AP-1 family of transcription factors; BCR signaling pathway; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Chagas disease (American trypanosomiasis); Cholinergic synapse; EGFR1 Signaling Pathway; EGFR1 Signaling Pathway; Endothelins; ErbB1 downstream signaling; ErbB2/ErbB3 signaling events; Estrogen signaling pathway; FGF signaling pathway; FOXA1 transcription factor network; HTLV-I infection

Gene Information

• Gene Name: FOS FBJ murine osteosarcoma viral oncogene homolog [ Homo sapiens ]
• Official Symbol: FOS
• Synonyms: FOS; FBJ murine osteosarcoma viral oncogene homolog; p55; AP-1; C-FOS; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
• Gene ID: 2353
• mRNA Refseq: NM_005252
• Protein Refseq: NP_005243
• MIM: 164810
• UniProt ID: P01100
• Chromosome Location: 14q24
• Function: R-SMAD binding; double-stranded DNA binding; promoter binding; protein heterodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding