Catalog # or name ...
LRRK2 (968-end) was expressed by baculovirus in Sf9 insect cells using an
N-terminal GST tag.
leucine-rich repeat kinase is a protein with an ankryin repeat region, a
leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS
domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in
LRRK2 are the most frequent known cause of autosomal dominant and
idiopathic Parkinson"s disease with prevalent mutations being found within
the GTPase and kinase domains. LRRK2 cooperates with MET to promote efficient
tumor cell growth and survival in various cancers. Down-regulation of LRRK2
in cultured tumor cells compromises MET activation and selectively reduces
downstream MET signaling to mTOR and STAT3.
Sf9 insect cells using baculovirus.
stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.1 mM EDTA, 0.25 mM DTT, 0.1
mM PMSF, 25% glycerol.
Store product at -70oC.
For optimal storage, aliquot target into smaller quantities after
centrifugation and store at recommended temperature. For most favorable
performance, avoid repeated handling and multiple freeze/thaw cycles.
Antigen Gene Information
LRRK2 leucine-rich repeat kinase 2 [ Homo
repeat kinase 2; PARK8; RIPK7; ROCO2; AURA17; DARDARIN; leucine-rich repeat
serine/threonine-protein kinase 2; augmented in rheumatoid arthritis 17;
ATP binding; GTP
binding; GTP-dependent protein kinase activity; GTPase activator activity;
NOT GTPase activity; MAP kinase kinase activity; nucleotide binding; protein
binding; protein homodimerization activity; protein kinase activity; protein
serine/threonine kinase activity; tubulin binding
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