Recombinant Human Platelet-Derived Growth Factor-BB

• Cat.No.: PDGFB-20H
• Product Overview: Platelet-Derived Growth Factor-BB produced inE. colihas a molecular mass of 27KD.

Specification

• Cat. No.: PDGFB-20H
• Description: Platelet-Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue. PDGF which is composed of a dimer of two chains termed the A chain and B chain, can be present as AA or BB homodimers or as an AB heterodimer. Recombinant human PDGF-BB is a24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). Human recombinant platelet-derived growth factor is expressed inE. coli.
• Purity: ≥95% as determined by SDS-PAGE.
• PI: 9.39 by Isoelectricfocusing
• concentration: 1 mg/ml by BCA
• Component: Platelet-Derived Growth Factor-BB, PBS buffer, pH 7.4
• Endotoxin: less than 10EU/mg as determined by LAL method
• Storage Buffer: Liquid. In PBS Buffer.
• Storagee: At 4°C for 6 months and -80°C for 2 years
• Publication:
  Magnetically Detected Protein Binding Using Spin-Labeled Slow Off-Rate Modified Aptamers (2023)
  Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets (2012)

Gene Information

• Gene Name: PDGFB
• Synonyms: FLJ12858; PDGF2; SIS; SSV; c-sis; Becaplermin; PDGF-2; SIS; SSV; becaplermin; c-sis; HUMANES PDGF-B GEN AUS PGEM2-PDGF-B, FLANKIERT VON 5"-ECORI UND3"-HINDIII RESTRIKTIONSSCHNITTSTELLEN;PDGFB_HUMAN;PDGF B-chain; PDGF, B chain; PDGF-B VORLAEUFERSEQUENZ; Platelet-derived growth factor B chain precursor; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor, beta polypeptide (oncogene SIS); oncogene SIS ; platelet-derived growth factor 2; platelet-derived growth factor beta; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor, B chain; v-sis platelet-derived growth factor beta polypeptide (simian sarcomaviral oncogene homolog); PDGFB
• Gene ID: 5155
• mRNA Refseq: NM_002608
• Protein Refseq: NP_002599
• MIM: 190040
• UniProt ID: P01127
• Chromosome Location: 22q12.3-q13.1; 22q13.1
• Pathway: Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma.
• Function: cell surface binding, growth factor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein binding, protein heterodimerization activity, protein homodimerization activity.