Recombinant Human Tau Tubulin Kinase 2, GST-tagged

• Cat.No.: TTBK2-1114H
• Product Overview: Recombinant mouse TTBK2 (70-538) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: TTBK2-1114H
• Description: TTBK2 or tau tubulin kinase 2 is a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. TTBK2 is a member of the casein kinase (CK1) group of eukaryotic protein kinases that is involved in tau phosphorylation and aggregation. Mutations in TTBK2 cause spinocerebellar ataxia type 11 (SCA11) (a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem).
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 88kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50mM Tris-HCI, pH 7.5, 150mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25% glycerol.
• Specific Activity: 370nmol/min/mg
• Purity: >95%
• Concentration: 0.1 ug/ul
• Sequences: 27-end
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.

Gene Information

• Gene Name: TTBK2 tau tubulin kinase 2 [ Homo sapiens ]
• Official Symbol: TTBK2
• Synonyms: TTBK2; tau tubulin kinase 2; TTBK; SCA11; KIAA0847; spinocerebellar ataxia 11; NP_775771.3; EC 2.7.11.1; tau-tubulin kinase; EC 2.7.11
• Gene ID: 146057
• mRNA Refseq: NM_173500
• Protein Refseq: NP_775771
• MIM: 611695
• UniProt ID: Q6IQ55
• Chromosome Location: 15q15.2
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity